| Reaction Details |
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 | Report a problem with these data |
| Target | Epoxide hydrolase 1 |
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| Ligand | BDBM50268321 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_523914 (CHEMBL1001507) |
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| IC50 | 24000±n/a nM |
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| Citation |  Shen, HC; Ding, FX; Wang, S; Xu, S; Chen, HS; Tong, X; Tong, V; Mitra, K; Kumar, S; Zhang, X; Chen, Y; Zhou, G; Pai, LY; Alonso-Galicia, M; Chen, X; Zhang, B; Tata, JR; Berger, JP; Colletti, SL Discovery of spirocyclic secondary amine-derived tertiary ureas as highly potent, selective and bioavailable soluble epoxide hydrolase inhibitors. Bioorg Med Chem Lett19:3398-404 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Epoxide hydrolase 1 |
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| Name: | Epoxide hydrolase 1 |
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| Synonyms: | EPHX | EPHX1 | EPOX | Epoxide hydrolase (EH) | Epoxide hydrolase (HsEH) | Epoxide hydrolase 1 | HYEP_HUMAN | Microsomal epoxide hydrolase |
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| Type: | Protein |
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| Mol. Mass.: | 52954.28 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P07099 |
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| Residue: | 455 |
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| Sequence: | MWLEILLTSVLGFAIYWFISRDKEETLPLEDGWWGPGTRSAAREDDSIRPFKVETSDEEI
HDLHQRIDKFRFTPPLEDSCFHYGFNSNYLKKVISYWRNEFDWKKQVEILNRYPHFKTKI
EGLDIHFIHVKPPQLPAGHTPKPLLMVHGWPGSFYEFYKIIPLLTDPKNHGLSDEHVFEV
ICPSIPGYGFSEASSKKGFNSVATARIFYKLMLRLGFQEFYIQGGDWGSLICTNMAQLVP
SHVKGLHLNMALVLSNFSTLTLLLGQRFGRFLGLTERDVELLYPVKEKVFYSLMRESGYM
HIQCTKPDTVGSALNDSPVGLAAYILEKFSTWTNTEFRYLEDGGLERKFSLDDLLTNVML
YWTTGTIISSQRFYKENLGQGWMTQKHERMKVYVPTGFSAFPFELLHTPEKWVRFKYPKL
ISYSYMVRGGHFAAFEEPELLAQDIRKFLSVLERQ
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| BDBM50268321 |
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| n/a |
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| Name | BDBM50268321 |
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| Synonyms: | 6-(methylsulfonyl)-N-((trans)-2-phenylcyclopropyl)spiro[chroman-2,4'-piperidine]-1'-carboxamide | CHEMBL519336 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H28N2O4S |
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| Mol. Mass. | 440.555 |
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| SMILES | CS(=O)(=O)c1ccc2OC3(CCN(CC3)C(=O)N[C@H]3C[C@@H]3c3ccccc3)CCc2c1 |r| |
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| Structure | 
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