Ki Summary

Reaction Details

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Target

Bifunctional epoxide hydrolase 2

Ligand

BDBM50268437

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_523916 (CHEMBL1001509)

IC50

11±n/a nM

Citation

Shen, HC; Ding, FX; Wang, S; Xu, S; Chen, HS; Tong, X; Tong, V; Mitra, K; Kumar, S; Zhang, X; Chen, Y; Zhou, G; Pai, LY; Alonso-Galicia, M; Chen, X; Zhang, B; Tata, JR; Berger, JP; Colletti, SL Discovery of spirocyclic secondary amine-derived tertiary ureas as highly potent, selective and bioavailable soluble epoxide hydrolase inhibitors. Bioorg Med Chem Lett19:3398-404 (2009) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Bifunctional epoxide hydrolase 2

Name:

Bifunctional epoxide hydrolase 2

Synonyms:

Ephx2 | Epoxide hydrolase 2 | HYES_RAT

Type:

PROTEIN

Mol. Mass.:

62337.15

Organism:

Rattus norvegicus

Description:

ChEMBL_1465995

Residue:

554

Sequence:

MALRVAAFDLDGVLALPSIAGVLRHTEEALALPRDFLLGAFQMKFPEGPTEQLMKGKITF
SQWVPLMDESCRKSSKACGASLPENFSISEIFSQAMAARSINRPMLQAAAALKKKGFTTC
IVTNNWLDDSDKRDILAQMMCELSQHFDFLIESCQVGMIKPEPQIYKFVLDTLKAKPNEV
VFLDDFGSNLKPARDMGMVTILVRDTASALRELEKVTGTQFPEAPLPVPCSPNDVSHGYV
TVKPGIRLHFVEMGSGPAICLCHGFPESWFSWRYQIPALAQAGFRVLAIDMKGYGDSSSP
PEIEEYAMELLCEEMVTFLNKLGIPQAVFIGHDWAGVLVWNMALFHPERVRAVASLNTPL
MPPNPEVSPMEVIRSIPVFNYQLYFQEPGVAEAELEKNMSRTFKSFFRTSDDMGLLTVNK
ATEMGGILVGTPEDPKVSKITTEEEIEYYIQQFKKSGFRGPLNWYRNTERNWKWSCKALG
RKILVPALMVTAEKDIVLRPEMSKNMENWIPFLKRGHIEDCGHWTQIEKPAEVNQILIKW
LKTEIQNPSVTSKI

BDBM50268437

n/a

Name

BDBM50268437

Synonyms:

(+/-)-N-((trans)-2-phenylcyclopropyl)spiro[chroman-2,4'-piperidine]-1'-carboxamide | CHEMBL495995

Type

Small organic molecule

Emp. Form.

C23H26N2O2

Mol. Mass.

362.4647

SMILES

O=C(N[C@H]1C[C@@H]1c1ccccc1)N1CCC2(CC1)CCc1ccccc1O2 |r|

Structure