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TargetProstaglandin G/H synthase 1/2
LigandBDBM22971
Substrate/Competitorn/a
Meas. Tech.ChEMBL_51497 (CHEMBL665832)
IC50 100±n/a nM
Citation Boschelli, DHConnor, DTHoefle, MBornemeier, DADyer, RD Conversion of NSAIDS into balanced dual inhibitors of cyclooxygenase and 5-lipoxygenase Bioorg Med Chem Lett2:69-72 (1992)    Article
More Info.:Get all data from this article,  Assay Method
 
Prostaglandin G/H synthase 1/2
Name:Prostaglandin G/H synthase 1/2
Synonyms:Cyclooxygenase
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of ChEMBL is 1666355
Components:This complex has 2 components.
Component 1
Name:Prostaglandin G/H synthase 2
Synonyms:Cox-2 | Cox2 | Cyclooxygenase | PGH2_RAT | Ptgs2
Type:Enzyme Catalytic Domain
Mol. Mass.:69173.51
Organism:RAT
Description:COX-2 0 RAT::P35355
Residue:604
Sequence:
MLFRAVLLCAALALSHAANPCCSNPCQNRGECMSIGFDQYKCDCTRTGFYGENCTTPEFL
TRIKLLLKPTPNTVHYILTHFKGVWNIVNNIPFLRNSIMRYVLTSRSHLIDSPPTYNVHY
GYKSWEAFSNLSYYTRALPPVADDCPTPMGVKGNKELPDSKEVLEKVLLRREFIPDPQGT
NMMFAFFAQHFTHQFFKTDQKRGPGFTRGLGHGVDLNHVYGETLDRQHKLRLFQDGKLKY
QVIGGEVYPPTVKDTQVDMIYPPHVPEHLRFAVGQEVFGLVPGLMMYATIWLREHNRVCD
ILKQEHPEWDDERLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQ
NRIASEFNTLYHWHPLLPDTFNIEDQEYTFKQFLYNNSILLEHGLAHFVESFTRQIAGRV
AGGRNVPIAVQAVAKASIDQSREMKYQSLNEYRKRFSLKPYTSFEELTGEKEMAAELKAL
YHDIDAMELYPALLVEKPRPDAIFGETMVELGAPFSLKGLMGNPICSPQYWKPSTFGGEV
GFRIINTASIQSLICNNVKGCPFASFNVQDPQPTKTATINASASHSRLDDINPTVLIKRR
STEL
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  Blast E-value cutoff:
Component 2
Name:Prostaglandin G/H synthase 1
Synonyms:Cox-1 | Cox1 | Cyclooxygenase | Cyclooxygenase-1 | PGH1_RAT | Prostaglandin G/H synthase (cyclooxygenase) | Ptgs1
Type:Enzyme Catalytic Domain
Mol. Mass.:69033.56
Organism:RAT
Description:COX-1 0 RAT::Q63921
Residue:602
Sequence:
MSRRSLSLQFPLLLLLLLLPPPPVLLTDAGVPSPVNPCCYYPCQNQGVCVRFGLDHYQCD
CTRTGYSGPNCTIPEIWTWLRSSLRPSPSFTHFLLTHGYWIWEFVNATFIREVLMRLVIT
VRSNLIPSPPTYNTAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDIHLLA
QRLLLRREFIPGPQGTNVLFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDSL
ERQYHLRLFKDGKLKYQVLDGEVYPPSVEQASVLMRYPPGVPPEKQMAVGQEVFGLLPGL
MLFSTIWLREHNRVCDLLKEEHPTWDDEQLFQTTRLILIGETIKIIIEEYVQHLSGYFLQ
LKFDPELLFRAQFQYRNRIALEFNHLYHWHPLMPDSFQVGSQEYSYEQFLFNTSMLVDYG
VEALVDAFSRQRAGRIGGGRNFDYHVLHVAEDVIKESREMRLQSFNEYRKRFGLKPYTSF
QEFTGEKEMAAELEELYGDIDALEFYPGLMLEKCQPNSLFGESMIEMGAPFSLKGLLGNP
ICSPEYWKPSTFGGDVGFNIVNTASLKKLVCLNTKTCPYVSFRVPDYPGDDGSVFVRPST
EL
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  Blast E-value cutoff:
BDBM22971
n/a
NameBDBM22971
Synonyms:2-[(2,6-dichloro-3-methylphenyl)amino]benzoic acid | CHEMBL509 | Meclofenamate | Meclofenamic acid | US11337935, Compound Meclofenamic-acid | US20240002326, Compound Meclofenamic acid
TypeSmall organic molecule
Emp. Form.C14H11Cl2NO2
Mol. Mass.296.149
SMILESCc1ccc(Cl)c(Nc2ccccc2C(O)=O)c1Cl
Structure
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