| Reaction Details |
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 | Report a problem with these data |
| Target | 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
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| Ligand | BDBM50280061 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_80655 |
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| IC50 | >4100±n/a nM |
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| Citation |  Balasubramanian, N; Brown, PJ; Parker, RA; Wright, JJ HMG-CoA reductase inhibitors 4. Tetrazole series: conformational constraints and structural requirements at the hydrophobic domain. Bioorg Med Chem Lett2:99-104 (1992) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
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| Name: | 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
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| Synonyms: | HMDH_RAT | HMG-CoA reductase | Hmgcr |
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| Type: | Enzyme |
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| Mol. Mass.: | 96689.85 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Isolated rat liver microsomes were used as enzyme source. |
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| Residue: | 887 |
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| Sequence: | MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSS
DIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTG
LNEALPFFLLLIDLSRASALAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIG
VGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFAR
VLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTAEQSKVSLGLAEDVSKR
IEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQAETESTLSLKNPITSPVVT
PKKAQDNCCRREPLLVRRNQKLSSVEEDPGVNQDRKVEVIKPLVAEAETSGRATFVLGAS
AASPPLALGAQEPGIELPSEPRPNEECLQILESAEKGAKFLSDAEIIQLVNAKHIPAYKL
ETLMETHERGVSIRRQLLSAKLAEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVA
GPLCLDGKEYQVPMATTEGCLVASTNRGCRAISLGGGASSRVLADGMSRGPVVRLPRACD
SAEVKSWLETPEGFAVVKEAFDSTSRFARLQKLHVTLAGRNLYIRLQSKTGDAMGMNMIS
KGTEKALLKLQEFFPELQILAVSGNYCTDKKPAAINWIEGRGKTVVCEAVIPAKVVREVL
KTTTEAMVDVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLM
EASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLARI
VCGTVMAGELSLMAALAAGHLVRSHMVHNRSKINLQDLQGTCTKKAA
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| BDBM50280061 |
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| n/a |
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| Name | BDBM50280061 |
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| Synonyms: | CHEMBL8633 | Sodium; (E)-8-(3,6-difluoro-fluoren-9-ylidene)-3,5-dihydroxy-8-(1-methyl-1H-tetrazol-5-yl)-oct-6-enoate |
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| Type | Small organic molecule |
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| Emp. Form. | C23H19F2N4O4 |
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| Mol. Mass. | 453.4187 |
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| SMILES | [#6]-n1nnnc1\[#6](\[#6]=[#6]\[#6](-[#8])-[#6]-[#6](-[#8])-[#6]-[#6](-[#8-])=O)=[#6]-1/c2ccc(F)cc2-c2cc(F)ccc-12 |
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| Structure | 
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