| Reaction Details |
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 | Report a problem with these data |
| Target | Thromboxane-A synthase |
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| Ligand | BDBM50280073 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_209929 |
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| IC50 | 50±n/a nM |
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| Citation |  Faull, AW; Gaskin, H; Hadfield, PS; Jessup, R; Russell, K; Watkins, WJ; Wayne, M Dual-acting thromboxane receptor antagonist/synthase inhibitors: heterocyclic variations Bioorg Med Chem Lett2:1181-1186 (1992) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thromboxane-A synthase |
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| Name: | Thromboxane-A synthase |
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| Synonyms: | CYP5 | CYP5A1 | Cytochrome P450 5A1 | P450 TxA2 | TBXAS1 | THAS_HUMAN | TXA synthase | TXAS | TXS | Thromboxane A2 Synthase | Thromboxane A2 Synthase (P450 TxA2) | Thromboxane Alpha | Thromboxane prostanoid | Thromboxane synthase | Thromboxane-A synthase |
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| Type: | Enzyme |
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| Mol. Mass.: | 60524.67 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P24557 |
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| Residue: | 533 |
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| Sequence: | MEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFR
QGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSV
ADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQR
CYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLA
RILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIV
RDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATN
PDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEV
LGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCL
GVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR
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| BDBM50280073 |
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| n/a |
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| Name | BDBM50280073 |
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| Synonyms: | (Z)-6-{(2S,4S,5R)-4-(3-Methyl-3H-imidazol-4-yl)-2-[1-methyl-1-(4-methyl-2-nitro-phenoxy)-ethyl]-[1,3]dioxan-5-yl}-hex-4-enoic acid | CHEMBL278714 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H31N3O7 |
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| Mol. Mass. | 473.5188 |
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| SMILES | Cc1ccc(OC(C)(C)[C@H]2OC[C@@H](C\C=C/CCC(O)=O)[C@H](O2)c2cncn2C)c(c1)[N+]([O-])=O |
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| Structure | 
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