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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | 5-hydroxytryptamine receptor 3A/3B | ||
| Ligand | BDBM50280509 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_3006 (CHEMBL619796) | ||
| Ki | 61±n/a nM | ||
| Citation |  Langlois, M; Soulier, JL; Brémont, B; Shen, S; Rampillon, V; Giudice, A Derivatives of naphthalimide: new potent conformationally restricted antagonists of 5-HT3 receptors. Bioorg Med Chem Lett2:691-694 (1992) Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| 5-hydroxytryptamine receptor 3A/3B | |||
| Name: | 5-hydroxytryptamine receptor 3A/3B | ||
| Synonyms: | Serotonin 3 (5-HT3) receptor | Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor | ||
| Type: | n/a | ||
| Mol. Mass.: | n/a | ||
| Description: | ASSAY_ID of EBI is 2974 | ||
| Components: | This complex has 2 components. | ||
| Component 1 | |||
| Name: | 5-hydroxytryptamine receptor 3B | ||
| Synonyms: | 5HT3B_RAT | Htr3b | Serotonin (5-HT) receptor | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 50328.78 | ||
| Organism: | Rattus norvegicus | ||
| Description: | EBI_11885 | ||
| Residue: | 437 | ||
| Sequence: |
| ||
| Component 2 | |||
| Name: | 5-hydroxytryptamine receptor 3A | ||
| Synonyms: | 5-HT3 | 5-hydroxytryptamine receptor 3A | 5HT3A_RAT | 5ht3 | Htr3 | Htr3a | Serotonin (5-HT) receptor | Zacopride site-R | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 55428.70 | ||
| Organism: | RAT | ||
| Description: | 5-HT3 HTR3A RAT::P35563 | ||
| Residue: | 483 | ||
| Sequence: |
| ||
| BDBM50280509 | |||
| n/a | |||
| Name | BDBM50280509 | ||
| Synonyms: | (S)-2-(1-Aza-bicyclo[2.2.2]oct-3-yl)-benzo[de]isoquinoline-1,3-dione | CHEMBL349472 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H18N2O2 | ||
| Mol. Mass. | 306.3584 | ||
| SMILES | O=C1N([C@@H]2CN3CCC2CC3)C(=O)c2cccc3cccc1c23 |wU:3.2,(2.36,-1.61,;1.51,-.33,;2.21,1.05,;3.75,1.14,;4.59,-.17,;6.13,-.08,;6.81,1.3,;5.97,2.58,;4.43,2.52,;4.83,1.02,;5.83,1.48,;1.38,2.36,;2.05,3.73,;-.18,2.26,;-.99,3.53,;-2.52,3.43,;-3.23,2.08,;-2.39,.82,;-3.1,-.56,;-2.26,-1.87,;-.73,-1.77,;-.02,-.42,;-.87,.89,)| | ||
| Structure | 
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