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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | 5-hydroxytryptamine receptor 3A/3B | ||
| Ligand | BDBM50280501 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_3006 (CHEMBL619796) | ||
| Ki | 41±n/a nM | ||
| Citation |  Langlois, M; Soulier, JL; Brémont, B; Shen, S; Rampillon, V; Giudice, A Derivatives of naphthalimide: new potent conformationally restricted antagonists of 5-HT3 receptors. Bioorg Med Chem Lett2:691-694 (1992) Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| 5-hydroxytryptamine receptor 3A/3B | |||
| Name: | 5-hydroxytryptamine receptor 3A/3B | ||
| Synonyms: | Serotonin 3 (5-HT3) receptor | Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor | ||
| Type: | n/a | ||
| Mol. Mass.: | n/a | ||
| Description: | ASSAY_ID of EBI is 2974 | ||
| Components: | This complex has 2 components. | ||
| Component 1 | |||
| Name: | 5-hydroxytryptamine receptor 3B | ||
| Synonyms: | 5HT3B_RAT | Htr3b | Serotonin (5-HT) receptor | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 50328.78 | ||
| Organism: | Rattus norvegicus | ||
| Description: | EBI_11885 | ||
| Residue: | 437 | ||
| Sequence: |
| ||
| Component 2 | |||
| Name: | 5-hydroxytryptamine receptor 3A | ||
| Synonyms: | 5-HT3 | 5-hydroxytryptamine receptor 3A | 5HT3A_RAT | 5ht3 | Htr3 | Htr3a | Serotonin (5-HT) receptor | Zacopride site-R | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 55428.70 | ||
| Organism: | RAT | ||
| Description: | 5-HT3 HTR3A RAT::P35563 | ||
| Residue: | 483 | ||
| Sequence: |
| ||
| BDBM50280501 | |||
| n/a | |||
| Name | BDBM50280501 | ||
| Synonyms: | 2-(1-Aza-bicyclo[2.2.2]oct-3-yl)-6-bromo-benzo[de]isoquinoline-1,3-dione | CHEMBL350423 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H17BrN2O2 | ||
| Mol. Mass. | 385.254 | ||
| SMILES | Brc1ccc2C(=O)N(C3CN4CCC3CC4)C(=O)c3cccc1c23 |(4.93,-5.21,;6.47,-5.14,;7.18,-3.77,;8.7,-3.69,;9.52,-4.95,;11.09,-4.86,;11.76,-3.48,;11.92,-6.17,;13.47,-6.08,;14.31,-7.37,;15.84,-7.3,;16.54,-5.92,;15.67,-4.63,;14.15,-4.7,;14.55,-6.2,;15.56,-5.73,;11.23,-7.55,;12.09,-8.84,;9.69,-7.65,;8.98,-9,;7.44,-9.09,;6.61,-7.78,;7.32,-6.4,;8.84,-6.33,)| | ||
| Structure | 
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