| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Caspase-1 |
|---|
| Ligand | BDBM12197 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_90983 |
|---|
| Ki | 19±n/a nM |
|---|
| Citation |  Mjalli, AM; Chapman, KT; MacCoss, M; Thornberry, NA Phenylalkyl ketones as potent reversible inhibitors of interleukin-1β converting enzyme Bioorg Med Chem Lett3:2689-2692 (1993) Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Caspase-1 |
|---|
| Name: | Caspase-1 |
|---|
| Synonyms: | CASP1 | CASP1_HUMAN | Caspase | Caspase 1 | ICE | IL1BC | IL1BCE | Interleukin-1 beta convertase | Interleukin-1 beta-converting enzyme |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 45154.13 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P29466 |
|---|
| Residue: | 404 |
|---|
| Sequence: | MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS
VIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDN
PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT
GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIR
EGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVG
VSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEY
ACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
|
|
|
|---|
| BDBM12197 |
|---|
| n/a |
|---|
| Name | BDBM12197 |
|---|
| Synonyms: | (3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanamido]-3-methylbutanamido]propanamido]-4-oxo-9-phenylnonanoic acid | tetrapeptide inhibitor 1 |
|---|
| Type | Small Organic Molecule |
|---|
| Emp. Form. | C34H46N4O8 |
|---|
| Mol. Mass. | 638.751 |
|---|
| SMILES | CC(C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)CCCCCc1ccccc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
