Ki Summary

Reaction Details

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Target

Gastrin/cholecystokinin type B receptor

Ligand

BDBM50281634

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_48763

1.7±n/a nM

Citation

Horwell, DC; Howson, W; Ratcliffe, GS; Rees, DC The design of a dipeptide library for screening at peptide receptor sites Bioorg Med Chem Lett3:799-802 (1993) Article

More Info.:

Get all data from this article, Assay Method

Gastrin/cholecystokinin type B receptor

Name:

Gastrin/cholecystokinin type B receptor

Synonyms:

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

48445.79

Organism:

Homo sapiens (Human)

Description:

Stable expression of human CCK-2 receptors in HEK 293 cells.

Residue:

447

Sequence:

MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITL
YAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTF
IFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWL
LSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGL
ISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRS
RPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDG
PGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRAL
PDEDPPTPSIASLSRLSYTTISTLGPG

BDBM50281634

n/a

Name

BDBM50281634

Synonyms:

3-{(R)-2-Amino-2-[(R)-2-(3-carboxy-propionylamino)-2-phenyl-ethylcarbamoyl]-propyl}-indole-1-carboxylic acid adamantan-2-yl ester | CHEMBL165869

Type

Small organic molecule

Emp. Form.

C35H42N4O6

Mol. Mass.

614.7312

SMILES

C[C@@](N)(Cc1cn(C(=O)OC2C3CC4CC(C3)CC2C4)c2ccccc12)C(=O)NC[C@H](NC(=O)CCC(O)=O)c1ccccc1 |wU:30.35,1.0,wD:1.1,TLB:16:11:19:15.17.14,16:15:10.11.12:19,THB:9:10:19:15.17.14,14:13:10:15.17.16,14:15:10:13.12.19,(2.53,-5.38,;2.53,-3.85,;1.17,-4.57,;2.6,-2.31,;1.29,-1.47,;-.16,-2.01,;-1.11,-.84,;-2.46,-1.57,;-2.49,-3.1,;-3.77,-.78,;-5.12,-1.52,;-5.28,-2.91,;-6.8,-3.17,;-8.17,-2.48,;-9.27,-3.57,;-7.75,-3.24,;-6.4,-3.99,;-7.61,-1.7,;-6.43,-.73,;-7.94,-.96,;-.27,.47,;-.69,1.95,;.4,3.03,;1.9,2.63,;2.29,1.17,;1.2,.07,;3.83,-4.67,;3.76,-6.22,;5.21,-3.96,;6.49,-4.78,;7.86,-4.06,;9.17,-4.89,;10.52,-4.17,;10.59,-2.63,;11.82,-5,;13.18,-4.29,;14.48,-5.1,;15.86,-4.39,;14.48,-6.64,;7.91,-2.54,;9.24,-1.72,;9.19,-.17,;7.84,.54,;6.53,-.28,;6.58,-1.79,)|

Structure