Ki Summary

Reaction Details

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Target

Renin

Ligand

BDBM50006844

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_196307

IC50

0.320000±n/a nM

Citation

Hamilton, H; Steinbaugh, B; Blankley, J; Taylor, M; Chan, OH; Stewart, B; Schroeder, R; Ryan, M; Rapundalo, S; Cook, J; Bernabei, A; Stewart, C Evaluation of the intestinal permeability and hepatic handling of peptidomimetic analogs Bioorg Med Chem Lett3:813-818 (1993) Article

More Info.:

Get all data from this article, Assay Method

Renin

Name:

Renin

Synonyms:

RENI_RAT | Ren | Ren1

Type:

PROTEIN

Mol. Mass.:

44272.67

Organism:

Rattus norvegicus

Description:

ChEMBL_222765

Residue:

402

Sequence:

MGGRRMPLWALLLLWTSCSFSLPTDTASFGRILLKKMPSVREILEERGVDMTRISAEWGE
FIKKSSFTNVTSPVVLTNYLDTQYYGEIGIGTPSQTFKVIFDTGSANLWVPSTKCGPLYT
ACEIHNLYDSSESSSYMENGTEFTIHYGSGKVKGFLSQDVVTVGGIIVTQTFGEVTELPL
IPFMLAKFDGVLGMGFPAQAVDGVIPVFDHILSQRVLKEEVFSVYYSRESHLLGGEVVLG
GSDPQHYQGNFHYVSISKAGSWQITMKGVSVGPATLLCEEGCMAVVDTGTSYISGPTSSL
QLIMQALGVKEKRANNYVVNCSQVPTLPDISFYLGGRTYTLSNMDYVQKNPFRNDDLCIL
ALQGLDIPPPTGPVWVLGATFIRKFYTEFDRHNNRIGFALAR

BDBM50006844

n/a

Name

BDBM50006844

Synonyms:

(S)-N-[(S)-2-(2-Amino-thiazol-4-yl)-1-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-ethyl]-2-(morpholine-4-sulfonylamino)-3-phenyl-propionamide | (S)-N-{(1S,2S)-2-(2-Amino-thiazol-4-yl)-1-[1-((S)-cyclohexylmethyl)-2,3-dihydroxy-5-methyl-hexylcarbamoyl]-ethyl}-2-((R)-morpholine-4-sulfonylamino)-3-phenyl-propionamide | CHEMBL34894 | CI-992 | N-[2-(2-Amino-thiazol-4-yl)-1-(1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-ethyl]-2-(morpholine-4-sulfonylamino)-3-phenyl-propionamide

Type

Small organic molecule

Emp. Form.

C33H52N6O7S2

Mol. Mass.

708.932

SMILES

CC(C)C[C@H](O)[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](Cc1csc(N)n1)NC(=O)[C@H](Cc1ccccc1)NS(=O)(=O)N1CCOCC1

Structure