Ki Summary

Reaction Details

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Target

Gastrin/cholecystokinin type B receptor

Ligand

BDBM50281984

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_40194

IC50

13±n/a nM

Citation

Eden, JM; Horwell, DC; Pritchard, MC α-β-didehydrotryptophan as a surrogate for α-methyltryptophan in CCK ‘peptoids’ related to CI-988. Bioorg Med Chem Lett3:989-992 (1993) Article

More Info.:

Get all data from this article, Assay Method

Gastrin/cholecystokinin type B receptor

Name:

Gastrin/cholecystokinin type B receptor

Synonyms:

Cckbr | Cholecystokinin A | Cholecystokinin receptor | GASR_MOUSE | Gastrin/cholecystokinin type B receptor

Type:

Enzyme Catalytic Domain

Mol. Mass.:

49196.59

Organism:

MOUSE

Description:

Cholecystokinin A CCKBR MOUSE::P56481

Residue:

453

Sequence:

MDLLKLNRSLQGPGPGSGSSLCRPGVSLLNSSSAGNLSCETPRIRGTGTRELELTIRITL
YAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTF
IFGTVICKAVSYLMGVSVSVSTLNLAAIALERYSAICRPLQARVWQTRSHAARVILATWL
LSGLLMVPYPVYTVVQPVGPRILQCMHLWPSERVQQMWSVLLLILLFFIPGVVMAVAYGL
ISRELYLGLRFDGDNDSETQSRVRNQGGLPGGAAAPGPVHQNGGCRHVTSLTGEDSDGCY
VQLPRSRLEMTTLTTPTTGPGPGPRPNQAKLLAKKRVVRMLLVIVLLFFVCWLPVYSANT
WRAFDGPGARRALAGAPISFIHLLSYTSACANPLVYCFMHRRFRQACLDTCARCCPRPPR
ARPRPLPDEDPPTPSIASLSRLSYTTISTLGPG

BDBM50281984

n/a

Name

BDBM50281984

Synonyms:

(S)-3-[(Z)-2-(Adamantan-2-yloxycarbonylamino)-3-(1H-indol-3-yl)-acryloylamino]-4-phenyl-butyric acid | (S)-3-[2-(Adamantan-2-yloxycarbonylamino)-3-(1H-indol-3-yl)-acryloylamino]-4-phenyl-butyric acid | CHEMBL368803

Type

Small organic molecule

Emp. Form.

C32H35N3O5

Mol. Mass.

541.6374

SMILES

OC(=O)C[C@H](Cc1ccccc1)NC(=O)C(Cc1c[nH]c2ccccc12)=NC(=O)OC1C2CC3CC(C2)CC1C3 |w:26.29,wD:4.12,TLB:36:31:39:35.37.34,36:35:30.31.32:39,THB:34:35:30:33.32.39,34:33:30:35.37.36,29:30:39:35.37.34,(11.61,.81,;12.26,-.59,;13.77,-.8,;11.3,-1.8,;11.86,-3.24,;13.38,-3.45,;14.8,-2.8,;14.94,-1.29,;16.33,-.64,;17.59,-1.52,;17.45,-3.08,;16.05,-3.71,;10.91,-4.43,;9.39,-4.22,;8.81,-2.78,;8.44,-5.41,;6.92,-5.2,;5.97,-6.41,;6.39,-7.9,;5.08,-8.76,;3.87,-7.79,;2.36,-8.04,;1.38,-6.85,;1.92,-5.41,;3.43,-5.15,;4.41,-6.34,;9,-6.85,;10.44,-7.39,;10.51,-8.93,;11.84,-6.74,;13.1,-7.65,;13.07,-9.35,;14.56,-9.93,;15.84,-9.25,;15.19,-10.58,;13.61,-10.04,;12.42,-10.56,;13.63,-8.09,;14.54,-6.92,;15.84,-7.69,)|

Structure