BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetThymidine kinase, cytosolic
LigandBDBM50282067
Substrate/Competitorn/a
Meas. Tech.ChEMBL_208022 (CHEMBL882138)
Ki 2900±n/a nM
Citation Kim, CUMisco, PFLuh, BYTerry, BBisacchi, GMansuri, MM (2R, 4S, 5S)-1-(tetrahydro-4-hydroxy-5-methoxy-2-furanyl)thymine: a potent selective inhibitor of herpes simplex thymidine kinase Bioorg Med Chem Lett3:1571-1576 (1993)    Article
More Info.:Get all data from this article,  Assay Method
 
Thymidine kinase, cytosolic
Name:Thymidine kinase, cytosolic
Synonyms:KITH_HUMAN | TK1
Type:PROTEIN
Mol. Mass.:25476.50
Organism:Homo sapiens (Human)
Description:ChEMBL_1333884
Residue:234
Sequence:
MSCINLPTVLPGSPSKTRGQIQVILGPMFSGKSTELMRRVRRFQIAQYKCLVIKYAKDTR
YSSSFCTHDRNTMEALPACLLRDVAQEALGVAVIGIDEGQFFPDIVEFCEAMANAGKTVI
VAALDGTFQRKPFGAILNLVPLAESVVKLTAVCMECFREAAYTKRLGTEKEVEVIGGADK
YHSVCRLCYFKKASGQPAGPDNKENCPVPGKPGEAVAARKLFAPQQILQCSPAN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50282067
n/a
NameBDBM50282067
Synonyms:1-((2R,4S,5S)-4-Hydroxy-5-methoxy-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione | CHEMBL289441
TypeSmall organic molecule
Emp. Form.C10H14N2O5
Mol. Mass.242.2286
SMILESCO[C@H]1O[C@H](C[C@@H]1O)n1cc(C)c(=O)[nH]c1=O
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: