| Reaction Details |
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 | Report a problem with these data |
| Target | Type-1 angiotensin II receptor |
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| Ligand | BDBM50282274 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_36945 (CHEMBL648848) |
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| IC50 | 0.1±n/a nM |
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| Citation |  Mantlo, NB; Kim, D; Ondeyka, D; Chang, RS; Kivlighn, SD; Siegl, PK; Greenlee, WJ Imidazo[4,5-b]pyridine-based AT1 / AT2 angiotensin II receptor antagonists Bioorg Med Chem Lett4:17-22 (1994) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Type-1 angiotensin II receptor |
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| Name: | Type-1 angiotensin II receptor |
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| Synonyms: | AGTR1 | AGTR1_RABIT | ANGIOTENSIN AT1 | Angiotensin II receptor | Angiotensin II type 1a (AT-1a) receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 41009.15 |
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| Organism: | RABBIT |
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| Description: | ANGIOTENSIN AT1 AGTR1 RABBIT::P34976 |
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| Residue: | 359 |
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| Sequence: | MMLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLAVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVC
AFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFK
IIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCRIADIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSSKKPVPCFEVE
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| BDBM50282274 |
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| n/a |
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| Name | BDBM50282274 |
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| Synonyms: | 4'-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-ylmethyl)-biphenyl-2-sulfonic acid (3-cyclopentyl-propionyl)-amide | CHEMBL68638 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H36N4O3S |
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| Mol. Mass. | 544.708 |
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| SMILES | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCC1CCCC1 |
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| Structure | 
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