| Reaction Details |
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 | Report a problem with these data |
| Target | Type-1 angiotensin II receptor |
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| Ligand | BDBM50282440 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_34643 (CHEMBL647288) |
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| IC50 | 8±n/a nM |
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| Citation |  Chakravarty, PK; Strelitz, RA; Chen, TB; Chang, RS; Lotti, VJ; Zingaro, GJ; Schorn, TW; Kivlighn, SD; Siegel, PK; Patchett, AA; Greenlee, WJ Quinazolinone Biphenyl Acylsulfonamides: A potent new class of angiotensin-II receptor antagonists Bioorg Med Chem Lett4:75-80 (1994) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Type-1 angiotensin II receptor |
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| Name: | Type-1 angiotensin II receptor |
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| Synonyms: | AGTR1 | AGTR1_RABIT | ANGIOTENSIN AT1 | Angiotensin II receptor | Angiotensin II type 1a (AT-1a) receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 41009.15 |
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| Organism: | RABBIT |
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| Description: | ANGIOTENSIN AT1 AGTR1 RABBIT::P34976 |
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| Residue: | 359 |
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| Sequence: | MMLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLAVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVC
AFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFK
IIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCRIADIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSSKKPVPCFEVE
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| BDBM50282440 |
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| n/a |
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| Name | BDBM50282440 |
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| Synonyms: | 4'-(2-Butyl-6-isopropyl-4-oxo-4H-quinazolin-3-ylmethyl)-biphenyl-2-sulfonic acid (thiophene-2-carbonyl)-amide | CHEMBL355443 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H33N3O4S2 |
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| Mol. Mass. | 599.763 |
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| SMILES | CCCCc1nc2ccc(cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)c1cccs1)C(C)C |
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| Structure | 
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