| Reaction Details |
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 | Report a problem with these data |
| Target | Type-2 angiotensin II receptor |
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| Ligand | BDBM50282451 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_35441 (CHEMBL643801) |
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| IC50 | 1500±n/a nM |
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| Citation |  Chakravarty, PK; Strelitz, RA; Chen, TB; Chang, RS; Lotti, VJ; Zingaro, GJ; Schorn, TW; Kivlighn, SD; Siegel, PK; Patchett, AA; Greenlee, WJ Quinazolinone Biphenyl Acylsulfonamides: A potent new class of angiotensin-II receptor antagonists Bioorg Med Chem Lett4:75-80 (1994) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Type-2 angiotensin II receptor |
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| Name: | Type-2 angiotensin II receptor |
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| Synonyms: | AGTR2_RAT | AT2 | Agtr2 | Angiotensin II AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Type-2 angiotensin II receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 41346.62 |
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| Organism: | RAT |
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| Description: | Angiotensin II AT2 0 0::P35351 |
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| Residue: | 363 |
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| Sequence: | MKDNFSFAATSRNITSSLPFDNLNATGTNESAFNCSHKPADKHLEAIPVLYYMIFVIGFA
VNIVVVSLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVF
GSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFY
FRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLK
TNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGIINSCEVIAVIDLAL
PFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSCRKSSSLREMDT
FVS
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| BDBM50282451 |
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| n/a |
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| Name | BDBM50282451 |
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| Synonyms: | 4'-(2-Butyl-6-dimethylamino-4-oxo-4H-quinazolin-3-ylmethyl)-biphenyl-2-sulfonic acid cyclopropanecarbonyl-amide | CHEMBL422374 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H34N4O4S |
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| Mol. Mass. | 558.691 |
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| SMILES | CCCCc1nc2ccc(cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)C1CC1)N(C)C |
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| Structure | 
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