| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Renin |
|---|
| Ligand | BDBM50282607 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_195791 (CHEMBL801712) |
|---|
| IC50 | 10±n/a nM |
|---|
| Citation |  Smith, SA; Al-Barazanji, KA; Buckingham, RE; Cassidy, F; Coldwell, MC; Finney, FJ; Hadley, MS; Ham, P; Lawrence, SA; Nash, DJ; Tingley, EJ; Watson, JM The identification of a novel renin inhibitor of equivalent efficacy following oral or intravenous administration. Bioorg Med Chem Lett4:1291-1296 (1994) Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Renin |
|---|
| Name: | Renin |
|---|
| Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 45058.99 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 406 |
|---|
| Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
|
|
|
|---|
| BDBM50282607 |
|---|
| n/a |
|---|
| Name | BDBM50282607 |
|---|
| Synonyms: | (3S,4S)-5-Cyclohexyl-4-((S)-2-{(S)-2-[2-(1,1-dioxo-2,3-dihydro-1H-1lambda*6*-benzo[b]thiophen-3-yl)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoylamino)-3-hydroxy-pentanoic acid (3-methyl-butyl)-amide | CHEMBL231043 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C41H60N4O7S |
|---|
| Mol. Mass. | 753.003 |
|---|
| SMILES | CC(C)CCNC(=O)C[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CC1CS(=O)(=O)c2ccccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
