Reaction Details |
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Target | Gag-Pol polyprotein [489-587] |
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Ligand | BDBM3414 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_79810 (CHEMBL696070) |
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IC50 | 1.5±n/a nM |
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Citation | Kaldor, SW; Hammond, M; Dressman, BA; Fritz, JE; Crowell, TA; Hermann, RA New dipeptide isosteres useful for the inhibition of HIV-1 protease Bioorg Med Chem Lett4:1385-1390 (1994) Article |
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More Info.: | Get all data from this article, Assay Method |
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Gag-Pol polyprotein [489-587] |
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Name: | Gag-Pol polyprotein [489-587] |
Synonyms: | Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 10781.16 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P04585[489-587] |
Residue: | 99 |
Sequence: | PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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BDBM3414 |
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n/a |
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Name | BDBM3414 |
Synonyms: | (2S)-N-[(2S,3R)-4-[2-(tert-butylcarbamoyl)phenyl]-3-hydroxy-1-phenylbutan-2-yl]-2-(quinolin-2-ylformamido)butanediamide | LY289612 |
Type | Small organic molecule |
Emp. Form. | C35H39N5O5 |
Mol. Mass. | 609.7147 |
SMILES | CC(C)(C)NC(=O)c1ccccc1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)c1ccc2ccccc2n1 |r| |
Structure |
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