| Reaction Details |
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 | Report a problem with these data |
| Target | Type-2 angiotensin II receptor |
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| Ligand | BDBM50283305 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_35442 (CHEMBL643802) |
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| IC50 | 0.210000±n/a nM |
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| Citation |  Glinka, TW; de Laszlo, SE; Siegl, PK; Chang, RS; Kivlighn, SD; Schorn, TS; Faust, KA; Chen, TB; Zingaro, GJ; Lotti, VJ; Greenlee, WJ Development of angiotensin II antagonists with equipotent affinity for human AT1 and AT2 receptor subtypes. Bioorg Med Chem Lett4:2337-2342 (1994) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Type-2 angiotensin II receptor |
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| Name: | Type-2 angiotensin II receptor |
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| Synonyms: | AGTR2_RAT | AT2 | Agtr2 | Angiotensin II AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Type-2 angiotensin II receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 41346.62 |
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| Organism: | RAT |
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| Description: | Angiotensin II AT2 0 0::P35351 |
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| Residue: | 363 |
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| Sequence: | MKDNFSFAATSRNITSSLPFDNLNATGTNESAFNCSHKPADKHLEAIPVLYYMIFVIGFA
VNIVVVSLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVF
GSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFY
FRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLK
TNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGIINSCEVIAVIDLAL
PFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSCRKSSSLREMDT
FVS
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| BDBM50283305 |
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| n/a |
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| Name | BDBM50283305 |
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| Synonyms: | 3'-Fluoro-4'-[6-(3-isopropyl-ureido)-4-oxo-2-propyl-4H-quinazolin-3-ylmethyl]-biphenyl-2-sulfonic acid 4-ethyl-2-fluoro-benzoylamide | CHEMBL305647 |
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| Type | Small organic molecule |
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| Emp. Form. | C37H37F2N5O5S |
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| Mol. Mass. | 701.782 |
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| SMILES | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)c1ccc(CC)cc1F |
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| Structure | 
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