| Reaction Details |
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 | Report a problem with these data |
| Target | Type-1 angiotensin II receptor |
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| Ligand | BDBM50284674 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_36628 |
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| IC50 | 1.1±n/a nM |
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| Citation |  de Laszlo, SE; Chang, RS; Chen, TB; Faust, KA; Greenlee, WJ; Kivlighn, SD; Lotti, VJ; O'Malley, SS; Schorn, TW; Schorn, TW; Siegl, PK; Tran, J; Zingaro, GJ The SAR of 6-(N-alkyl-N-acyl)-2-propyl-3-[(2′-tetrazol-5-yl)biphen-4-yl)methyl]-quinazolinones as balanced affinity antagonists of the human AT1 and AT2 receptors Bioorg Med Chem Lett5:1359-1364 (1995) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Type-1 angiotensin II receptor |
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| Name: | Type-1 angiotensin II receptor |
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| Synonyms: | AGTR1 | AGTR1_RABIT | ANGIOTENSIN AT1 | Angiotensin II receptor | Angiotensin II type 1a (AT-1a) receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 41009.15 |
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| Organism: | RABBIT |
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| Description: | ANGIOTENSIN AT1 AGTR1 RABBIT::P34976 |
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| Residue: | 359 |
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| Sequence: | MMLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLAVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVC
AFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFK
IIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCRIADIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSSKKPVPCFEVE
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| BDBM50284674 |
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| n/a |
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| Name | BDBM50284674 |
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| Synonyms: | 2-Methoxy-N-{3-[2'-(1-methyl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4-oxo-3,4-dihydro-quinazolin-6-yl}-N-pentyl-benzamide | CHEMBL282167 |
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| Type | Small organic molecule |
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| Emp. Form. | C36H35N7O3 |
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| Mol. Mass. | 613.7082 |
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| SMILES | CCCCCN(C(=O)c1ccccc1OC)c1ccc2ncn(Cc3ccc(cc3)-c3ccccc3-c3nnnn3C)c(=O)c2c1 |
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| Structure | 
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