Reaction Details |
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Target | Type-1 angiotensin II receptor |
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Ligand | BDBM50284677 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_36628 |
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IC50 | 3.4±n/a nM |
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Citation | de Laszlo, SE; Chang, RS; Chen, TB; Faust, KA; Greenlee, WJ; Kivlighn, SD; Lotti, VJ; O'Malley, SS; Schorn, TW; Schorn, TW; Siegl, PK; Tran, J; Zingaro, GJ The SAR of 6-(N-alkyl-N-acyl)-2-propyl-3-[(2′-tetrazol-5-yl)biphen-4-yl)methyl]-quinazolinones as balanced affinity antagonists of the human AT1 and AT2 receptors Bioorg Med Chem Lett5:1359-1364 (1995) Article |
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More Info.: | Get all data from this article, Assay Method |
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Type-1 angiotensin II receptor |
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Name: | Type-1 angiotensin II receptor |
Synonyms: | AGTR1 | AGTR1_RABIT | ANGIOTENSIN AT1 | Angiotensin II receptor | Angiotensin II type 1a (AT-1a) receptor |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 41009.15 |
Organism: | RABBIT |
Description: | ANGIOTENSIN AT1 AGTR1 RABBIT::P34976 |
Residue: | 359 |
Sequence: | MMLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLAVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVC
AFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFK
IIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCRIADIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSSKKPVPCFEVE
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BDBM50284677 |
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n/a |
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Name | BDBM50284677 |
Synonyms: | CHEMBL29063 | N-Benzyl-N-{3-[2'-(1-methyl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4-oxo-3,4-dihydro-quinazolin-6-yl}-isonicotinamide |
Type | Small organic molecule |
Emp. Form. | C36H28N8O2 |
Mol. Mass. | 604.6599 |
SMILES | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(cc3c2=O)N(Cc2ccccc2)C(=O)c2ccncc2)cc1 |
Structure |
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