| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Type-1 angiotensin II receptor |
|---|
| Ligand | BDBM50284655 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_36627 |
|---|
| IC50 | 6±n/a nM |
|---|
| Citation |  de Laszlo, SE; Chang, RS; Chen, TB; Faust, KA; Greenlee, WJ; Kivlighn, SD; Lotti, VJ; O'Malley, SS; Schorn, TW; Schorn, TW; Siegl, PK; Tran, J; Zingaro, GJ The SAR of 6-(N-alkyl-N-acyl)-2-propyl-3-[(2′-tetrazol-5-yl)biphen-4-yl)methyl]-quinazolinones as balanced affinity antagonists of the human AT1 and AT2 receptors Bioorg Med Chem Lett5:1359-1364 (1995) Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Type-1 angiotensin II receptor |
|---|
| Name: | Type-1 angiotensin II receptor |
|---|
| Synonyms: | AGTR1 | AGTR1A | AGTR1B | AGTR1_HUMAN | AT1 | AT1AR | AT1BR | AT2R1 | AT2R1B | Angiotensin II AT1 | Angiotensin II receptor | Angiotensin II type 1b (AT-1b) receptor | Type-1 angiotensin II receptor (AT1) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 41080.75 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P30556 |
|---|
| Residue: | 359 |
|---|
| Sequence: | MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVC
AFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFK
IIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
|
|
|
|---|
| BDBM50284655 |
|---|
| n/a |
|---|
| Name | BDBM50284655 |
|---|
| Synonyms: | CHEMBL30015 | N-(4-Hydroxy-benzyl)-N-{3-[2'-(1-methyl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4-oxo-3,4-dihydro-quinazolin-6-yl}-benzamide |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C37H29N7O3 |
|---|
| Mol. Mass. | 619.6713 |
|---|
| SMILES | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(cc3c2=O)N(Cc2ccc(O)cc2)C(=O)c2ccccc2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
