| Reaction Details |
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 | Report a problem with these data |
| Target | Polyunsaturated fatty acid 5-lipoxygenase |
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| Ligand | BDBM50284680 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_3964 |
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| IC50 | 1900±n/a nM |
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| Citation |  Andrews, EG; Antognoli, GW; Breslow, R; Carta, MP; Carty, TJ; Chambers, RJ; Cheng, JB; Cohan, VL; Collins, JL; Damon, DB; Delehunt, J; Eggler, JF; Eskra, JD; Freiert, KW; Hada, WA; Marfat, A; Masamune, H; Melvin, LS; Mularski, CJ; Naclerio, BA Synthesis and pharmacological profile of two novel heterocyclic chromanols, CP-80,798 and CP-85,958, as potent LTD4 receptor antagonists Bioorg Med Chem Lett5:1365-1370 (1995) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Polyunsaturated fatty acid 5-lipoxygenase |
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| Name: | Polyunsaturated fatty acid 5-lipoxygenase |
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| Synonyms: | Alox5 | Arachidonate 5-lipoxygenase | LOX5_RAT |
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| Type: | PROTEIN |
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| Mol. Mass.: | 78082.31 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1432947 |
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| Residue: | 673 |
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| Sequence: | MPSYTVTVATGSQWFAGTDDYIYLSLIGSAGCSEKHLLDKAFYNDFERGGRDSYDVTVDE
ELGEIYLVKIEKRKYRLHDDWYLKYITLKTPHDYIEFPCYRWITGEGEIVLRDGCAKLAR
DDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLN
YSKAMENLFINRFMHMFQSSWHDFADFEKIFVKISNTISERVKNHWQEDLMFGYQFLNGC
NPVLIKRCTELPKKLPVTTEMVECSLERQLSLEQEVQEGNIFIVDYELLDGIDANKTDPC
THQFLAAPICLLYKNLANKIVPIAIQLNQTPGEKNPIFLPTDSKYDWLLAKIWVRSSDFH
IHQTITHLLRTHLVSEVFGIAMYRQLPAVHPLFKLLVAHVRFTIAINTKAREQLNCEYGL
FDKANATGGGGHVQMVQRAVQDLTYSSLCFPEAIKARGMDNTEDIPYYFYRDDGLLVWEA
IQSFTTEVVSIYYEDDQVVEEDQELQDFVKDVYVYGMRGRKASGFPKSIKSREKLSEYLT
VVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWH
LGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMIRFRKNLEAIVSVIAERNKNKKLPYY
YLSPDRIPNSVAI
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| BDBM50284680 |
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| n/a |
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| Name | BDBM50284680 |
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| Synonyms: | (3S,4S)-3-Pyridin-3-ylmethyl-6-(quinolin-2-ylmethoxy)-chroman-4-ol | 3-Pyridin-3-ylmethyl-6-(quinolin-2-ylmethoxy)-chroman-4-ol | CHEMBL282524 | CP-80798 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H22N2O3 |
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| Mol. Mass. | 398.4538 |
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| SMILES | O[C@H]1[C@@H](Cc2cccnc2)COc2ccc(OCc3ccc4ccccc4n3)cc12 |
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| Structure | 
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