| Reaction Details |
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 | Report a problem with these data |
| Target | Sterol O-acyltransferase 1 |
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| Ligand | BDBM50450327 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_28027 |
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| IC50 | 3310±n/a nM |
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| Citation |  Wilde, RJ; Billheimer, JT; Germain, SJ; Gillies, PJ; Higley, CA; Kezar, HS; Maduskuie, TP; Shimshick, ES; Wexler, RR Acyl CoA:cholesterol acyltransferase (ACAT) inhibitors: ureas bearing heterocyclic groups bioisosteric for an imidazole Bioorg Med Chem Lett5:167-72 (1995) |
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| More Info.: | Get all data from this article, Assay Method |
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| Sterol O-acyltransferase 1 |
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| Name: | Sterol O-acyltransferase 1 |
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| Synonyms: | ACAT-1 | Acact | Acetoacetyl-CoA thiolase | Acetyl-CoA acetyltransferase, mitochondrial | Acyl coenzyme A:cholesterol acyltransferase 1 | Acyl-coenzyme A:cholesterol acyltransferase 1 | Cholesterol acyltransferase 1 | SOAT1_MOUSE | Soat1 | Sterol O-acyltransferase 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 63818.83 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_90523 |
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| Residue: | 540 |
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| Sequence: | MSLRNRLSKSGENPEQDEAQKNFMDTYRNGHITMKQLIAKKRLLAAEAEELKPLFMKEVG
CHFDDFVTNLIEKSASLDNGGCALTTFSILEEMKKNHRAKDLRAPPEQGKIFISRQSLLD
ELFEVDHIRTIYHMFIALLILFVLSTIVVDYIDEGRLVLEFNLLAYAFGKFPTVIWTWWA
MFLSTLSIPYFLFQRWAHGYSKSSHPLIYSLVHGLLFLVFQLGVLGFVPTYVVLAYTLPP
ASRFILILEQIRLIMKAHSFVRENIPRVLNAAKEKSSKDPLPTVNQYLYFLFAPTLIYRD
NYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSI
LPGVLILFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYY
YVYKDLLWFFSKRFKSAAMLAVFALSAVVHEYALAICLSYFYPVLFVLFMFFGMAFNFIV
NDSRKRPIWNIMVWASLFLGYGLILCFYSQEWYARQHCPLKNPTFLDYVRPRTWTCRYVF
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| BDBM50450327 |
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| n/a |
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| Name | BDBM50450327 |
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| Synonyms: | CHEMBL300518 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H32F2N6OS |
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| Mol. Mass. | 490.612 |
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| SMILES | CCCCCCCN(CCCCCSc1[nH]cnc2nncc12)C(=O)Nc1ccc(F)cc1F |
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| Structure | 
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