Reaction Details |
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Target | Sterol O-acyltransferase 1 |
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Ligand | BDBM50450318 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_28027 |
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IC50 | 5470±n/a nM |
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Citation | Wilde, RJ; Billheimer, JT; Germain, SJ; Gillies, PJ; Higley, CA; Kezar, HS; Maduskuie, TP; Shimshick, ES; Wexler, RR Acyl CoA:cholesterol acyltransferase (ACAT) inhibitors: ureas bearing heterocyclic groups bioisosteric for an imidazole Bioorg Med Chem Lett5:167-72 (1995) |
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More Info.: | Get all data from this article, Assay Method |
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Sterol O-acyltransferase 1 |
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Name: | Sterol O-acyltransferase 1 |
Synonyms: | ACAT-1 | Acact | Acetoacetyl-CoA thiolase | Acetyl-CoA acetyltransferase, mitochondrial | Acyl coenzyme A:cholesterol acyltransferase 1 | Acyl-coenzyme A:cholesterol acyltransferase 1 | Cholesterol acyltransferase 1 | SOAT1_MOUSE | Soat1 | Sterol O-acyltransferase 1 |
Type: | PROTEIN |
Mol. Mass.: | 63818.83 |
Organism: | Mus musculus |
Description: | ChEMBL_90523 |
Residue: | 540 |
Sequence: | MSLRNRLSKSGENPEQDEAQKNFMDTYRNGHITMKQLIAKKRLLAAEAEELKPLFMKEVG
CHFDDFVTNLIEKSASLDNGGCALTTFSILEEMKKNHRAKDLRAPPEQGKIFISRQSLLD
ELFEVDHIRTIYHMFIALLILFVLSTIVVDYIDEGRLVLEFNLLAYAFGKFPTVIWTWWA
MFLSTLSIPYFLFQRWAHGYSKSSHPLIYSLVHGLLFLVFQLGVLGFVPTYVVLAYTLPP
ASRFILILEQIRLIMKAHSFVRENIPRVLNAAKEKSSKDPLPTVNQYLYFLFAPTLIYRD
NYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSI
LPGVLILFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYY
YVYKDLLWFFSKRFKSAAMLAVFALSAVVHEYALAICLSYFYPVLFVLFMFFGMAFNFIV
NDSRKRPIWNIMVWASLFLGYGLILCFYSQEWYARQHCPLKNPTFLDYVRPRTWTCRYVF
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BDBM50450318 |
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n/a |
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Name | BDBM50450318 |
Synonyms: | CHEMBL49398 |
Type | Small organic molecule |
Emp. Form. | C24H31F2N5OS |
Mol. Mass. | 475.598 |
SMILES | CCCCCCN(CCCCCSc1nc2ccc[nH]c2n1)C(=O)Nc1ccc(F)cc1F |
Structure |
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