| Reaction Details |
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 | Report a problem with these data |
| Target | Gastrin/cholecystokinin type B receptor |
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| Ligand | BDBM50285463 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_47817 (CHEMBL662559) |
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| IC50 | 0.730000±n/a nM |
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| Citation |  Chambers, MS; Hobbs, SC; Graham, MI; Watt, AP; Fletcher, SR; Baker, R; Freedman, SB; Patel, S; Smith, AJ; Matassa, VG Potent, selective, water-soluble benzodiazepine-based CCKB receptor antagonists that contain lipophilic carboxylate surrogates Bioorg Med Chem Lett5:2303-2308 (1995) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Gastrin/cholecystokinin type B receptor |
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| Name: | Gastrin/cholecystokinin type B receptor |
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| Synonyms: | CCK-2 receptor | CCK-B receptor | CCK-BR | CCKBR | CCKRB | Cholecystokinin A | Cholecystokinin receptor | Cholecystokinin-2 Receptor | GASR_HUMAN | Gastrin/cholecystokinin type B receptor |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 48445.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Stable expression of human CCK-2 receptors in HEK 293 cells. |
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| Residue: | 447 |
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| Sequence: | MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITL
YAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTF
IFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWL
LSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGL
ISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRS
RPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDG
PGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRAL
PDEDPPTPSIASLSRLSYTTISTLGPG
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| BDBM50285463 |
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| n/a |
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| Name | BDBM50285463 |
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| Synonyms: | CHEMBL311154 | N-{3-[3-((R)-5-Cyclohexyl-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-ureido]-benzoyl}-benzenesulfonamide |
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| Type | Small organic molecule |
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| Emp. Form. | C30H31N5O5S |
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| Mol. Mass. | 573.663 |
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| SMILES | CN1c2ccccc2C(=N[C@@H](NC(=O)Nc2cccc(c2)C(=O)NS(=O)(=O)c2ccccc2)C1=O)C1CCCCC1 |c:9| |
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| Structure | 
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