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TargetCysteinyl leukotriene receptor 1
LigandBDBM50285679
Substrate/Competitorn/a
Meas. Tech.ChEMBL_99994 (CHEMBL710519)
IC50 2.43±n/a nM
Citation Labelle, MGareau, YDufresne, CLau, CKBelley, MJones, TRLeblanc, YMcAuliffe, MMcFarlane, CSMetters, KMOuimet, NPerrier, HRochette, CSawyer, NSlipetz, DXiang, YBWang, ZPickett, CBFord-Hutchinson, AWYoung, RN Discovery of L-740,515, a potent thienopyridine cysLT1 receptor (LTD4 receptor) antagonist Bioorg Med Chem Lett5:2551-2556 (1995)    Article
More Info.:Get all data from this article,  Assay Method
 
Cysteinyl leukotriene receptor 1
Name:Cysteinyl leukotriene receptor 1
Synonyms:CLTR1_HUMAN | CYSLT1 | CYSLTR1 | Cysteinyl leukotriene D4 receptor | Cysteinyl leukotriene receptor | Cysteinyl leukotriene receptor 1 | HG55 | HMTMF81 | LTD4 receptor | Leukotriene Cysteinyl 1
Type:Enzyme Catalytic Domain
Mol. Mass.:38565.16
Organism:Homo sapiens (Human)
Description:Leukotriene Cysteinyl 1 CYSLTR1 HUMAN::Q9Y271
Residue:337
Sequence:
MDETGNLTVSSATCHDTIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQV
YMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFF
RCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDN
QTKNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKKAIGMIMVVTA
AFLVSFMPYHIQRTIHLHFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGG
NFRKRLSTFRKHSLSSVTYVPRKKASLPEKGEEICKV
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  Blast E-value cutoff:
BDBM50285679
n/a
NameBDBM50285679
Synonyms:CHEMBL85572 | [1-((R)-3-(2-Bromo-phenyl)-1-{3-[(E)-2-(2,3-dichloro-thieno[3,2-b]pyridin-5-yl)-vinyl]-phenyl}-propylsulfanylmethyl)-cyclopropyl]-acetic acid
TypeSmall organic molecule
Emp. Form.C30H26BrCl2NO2S2
Mol. Mass.647.473
SMILESOC(=O)CC1(CS[C@H](CCc2ccccc2Br)c2cccc(\C=C\c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1
Structure
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