| Reaction Details |
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 | Report a problem with these data |
| Target | Gastrin/cholecystokinin type B receptor |
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| Ligand | BDBM50286151 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_49412 |
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| IC50 | 900±n/a nM |
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| Citation |  Holladay, MW; Bennett, MJ; Bai, H; Ralston, JW; Kerwin, JF; Stashko, M; Miller, TR; O'Neill, AB; Nadzan, AM; Brioni, J; Lin, CW Amino acid-derived piperidides as novel CCKB ligands with anxiolytic-like properties Bioorg Med Chem Lett5:3057-3062 (1995) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Gastrin/cholecystokinin type B receptor |
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| Name: | Gastrin/cholecystokinin type B receptor |
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| Synonyms: | CCK-2 receptor | CCK-B receptor | CCK-BR | CCKBR | CCKRB | Cholecystokinin A | Cholecystokinin receptor | Cholecystokinin-2 Receptor | GASR_HUMAN | Gastrin/cholecystokinin type B receptor |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 48445.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Stable expression of human CCK-2 receptors in HEK 293 cells. |
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| Residue: | 447 |
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| Sequence: | MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITL
YAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTF
IFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWL
LSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGL
ISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRS
RPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDG
PGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRAL
PDEDPPTPSIASLSRLSYTTISTLGPG
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| BDBM50286151 |
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| n/a |
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| Name | BDBM50286151 |
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| Synonyms: | (R)-5-(4-Benzoyl-piperidin-1-yl)-5-oxo-4-(3-m-tolyl-ureido)-pentanoic acid benzyl ester | 5-(4-Benzoyl-piperidin-1-yl)-5-(R)-oxo-4-(3-m-tolyl-ureido)-pentanoic acid benzyl ester | CHEMBL103276 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H35N3O5 |
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| Mol. Mass. | 541.6374 |
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| SMILES | Cc1cccc(NC(=O)N[C@H](CCC(=O)OCc2ccccc2)C(=O)N2CCC(CC2)C(=O)c2ccccc2)c1 |
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| Structure | 
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