| Reaction Details |
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 | Report a problem with these data |
| Target | Cysteinyl leukotriene receptor 1 |
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| Ligand | BDBM50286253 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_99859 (CHEMBL706929) |
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| IC50 | 0.790000±n/a nM |
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| Citation |  Labelle, M; Belley, M; Gareau, Y; Gauthier, JY; Guay, D; Gordon, R; Grossman, SG; Jones, TR; Leblanc, Y; McAuliffe, M; McFarlane, C; Masson, P; Metters, KM; Ouimet, N; Patrick, DH; Piechuta, H; Rochette, C; Sawyer, N; Xiang, YB; Pickett, CB Discovery of MK-0476, a potent and orally active leukotriene D4 receptor antagonist devoid of peroxisomal enxyme induction Bioorg Med Chem Lett5:283-288 (1995) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cysteinyl leukotriene receptor 1 |
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| Name: | Cysteinyl leukotriene receptor 1 |
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| Synonyms: | CLTR1_CAVPO | CYSLTR1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 39007.58 |
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| Organism: | GUINEA PIG |
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| Description: | Leukotriene D4 0 GUINEA PIG::Q2NNR5 |
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| Residue: | 340 |
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| Sequence: | MDETGNPTIPPASNNTCYDSIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLVKTYHEKSA
FQVYMINLAVADLLCVCTLPLRVAYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAM
SFFRCVAIVFPVQNISLVTQKKARLVCIAIWMFVILTSSPFLMANTYKDEKNNTKCFEPP
QDNQAKNYVLILHYVSLFIGFIIPFITIIVCYTMIIFTLLKSSMKKNLSSRKRAIGMIIV
VTAAFLVSFMPYHIQRTIHLHFLHNKTKPCDSILRMQKSVVITLSLAASNCCFDPLLYFF
SGGNFRRRLSTIRKYSLSSMTYIPKKKTSLPQKGKDICKE
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| BDBM50286253 |
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| n/a |
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| Name | BDBM50286253 |
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| Synonyms: | (S)-3-{(R)-1-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propylsulfanyl}-butyric acid | CHEMBL96986 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H34ClNO3S |
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| Mol. Mass. | 560.146 |
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| SMILES | C[C@@H](CC(O)=O)S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(\C=C\c2ccc3ccc(Cl)cc3n2)c1 |
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| Structure | 
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