| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin B |
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| Ligand | BDBM50286434 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_47409 |
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| IC50 | 25000±n/a nM |
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| Citation |  Graybill, TL; Dolle, RE; Osifo, IK; Schmidt, SJ; Gregory, JS; Harris, AL; Miller, MS Inhibition of human erythrocyte calpain I by novel quinolinecarboxamides Bioorg Med Chem Lett5:387-392 (1995) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin B |
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| Name: | Cathepsin B |
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| Synonyms: | APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 37819.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_63102437 |
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| Residue: | 339 |
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| Sequence: | MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCG
TFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDR
ICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCR
PYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM
AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSW
NTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
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| BDBM50286434 |
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| n/a |
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| Name | BDBM50286434 |
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| Synonyms: | 1-(2-Chloro-4-hydroxy-phenyl)-4-oxo-7-pyridin-4-yl-1,4-dihydro-quinoline-3-carboxylic acid amide | CHEMBL340384 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H14ClN3O3 |
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| Mol. Mass. | 391.807 |
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| SMILES | NC(=O)c1cn(-c2ccc(O)cc2Cl)c2cc(ccc2c1=O)-c1ccncc1 |
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| Structure | 
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