Reaction Details |
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Target | Calpain small subunit 1/1 catalytic subunit |
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Ligand | BDBM50073850 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_43696 (CHEMBL653673) |
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IC50 | 40±n/a nM |
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Citation | Harris, AL; Gregory, JS; Maycock, AL; Graybill, TL; Osifo, IK; Schmidt, SJ; Dolle, RE Characterization of a continuous fluorogenic assay for calpain I. Kinetic evaluation of peptide aldehydes, halomethyl ketones and (acyloxy)methyl ketones as inhibitors of the enzyme Bioorg Med Chem Lett5:393-398 (1995) Article |
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More Info.: | Get all data from this article, Assay Method |
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Calpain small subunit 1/1 catalytic subunit |
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Name: | Calpain small subunit 1/1 catalytic subunit |
Synonyms: | Calpain 1 | Calpain 1/small subunit 1 |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of EBI is 43671 |
Components: | This complex has 2 components. |
Component 1 |
Name: | Calpain small subunit 1 |
Synonyms: | CAPN4 | CAPNS | CAPNS1 | CPNS1_HUMAN | Calpain 1 |
Type: | PROTEIN |
Mol. Mass.: | 28309.36 |
Organism: | Homo sapiens (Human) |
Description: | EBI_12682 |
Residue: | 268 |
Sequence: | MFLVNSFLKGGGGGGGGGGGLGGGLGNVLGGLISGAGGGGGGGGGGGGGGGGGGGGTAMR
ILGGVISAISEAAAQYNPEPPPPRTHYSNIEANESEEVRQFRRLFAQLAGDDMEVSATEL
MNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQ
FDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMF
RAFKSLDKDGTGQIQVNIQEWLQLTMYS
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Component 2 |
Name: | Calpain-1 catalytic subunit |
Synonyms: | CAN1_HUMAN | CANPL1 | CAPN1 | Calpain ยต-type | Calpain-1 (u-Calpain) | Calpain-1 catalytic subunit | Calpain1 |
Type: | Protein |
Mol. Mass.: | 81880.51 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 714 |
Sequence: | MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEA
FPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAA
IASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPIKDGKLVFVHS
AEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILK
ALERGSLLGCSIDISSVLDMEAITFKKLVKGHAYSVTGAKQVNYRGQVVSLIRMRNPWGE
VEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSFRDFMREFTRLEICNLTPDALKS
RTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDRESGCSFV
LALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASRARSEQFINL
REVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQANLPDEQVLSE
EEIDENFKALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRD
GNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELII
TRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA
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BDBM50073850 |
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n/a |
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Name | BDBM50073850 |
Synonyms: | (S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-phenyl-propionic acid | CHEMBL423112 | MDL-28170 | [(S)-1-(1-Benzyl-2-oxo-ethylcarbamoyl)-2-methyl-propyl]-carbamic acid benzyl ester | [1-(1-Benzyl-2-oxo-ethylcarbamoyl)-2-methyl-propyl]-carbamic acid benzyl ester | [1-(1-Formyl-2-phenyl-ethylcarbamoyl)-2-methyl-propyl]-carbamic acid benzyl ester | benzyl (2S)-3-methyl-1-oxo-1-(1-oxo-3-phenylpropan-2-ylamino)butan-2-ylcarbamate | benzyl (S)-3-methyl-1-oxo-1-(1-oxo-3-phenylpropan-2-ylamino)butan-2-ylcarbamate |
Type | Small organic molecule |
Emp. Form. | C22H26N2O4 |
Mol. Mass. | 382.4528 |
SMILES | CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)NC(Cc1ccccc1)C=O |r| |
Structure |
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