| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Reverse transcriptase/RNaseH |
|---|
| Ligand | BDBM50286545 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_196368 (CHEMBL806001) |
|---|
| IC50 | >300000±n/a nM |
|---|
| Citation |  Young, SD; Amblard, MC; Britcher, SF; Grey, VE; Tran, LO; Lumma, WC; Huff, JR; Schleif, WA; Emini, EE; O'Brien, JA; Pettibone, DJ 2-Heterocyclic indole-3-sulfones as inhibitors of HIV-1 reverse transcriptase Bioorg Med Chem Lett5:491-496 (1995) Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Reverse transcriptase/RNaseH |
|---|
| Name: | Reverse transcriptase/RNaseH |
|---|
| Synonyms: | HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 65229.15 |
|---|
| Organism: | Human immunodeficiency virus 1 |
|---|
| Description: | ChEMBL_1473730 |
|---|
| Residue: | 566 |
|---|
| Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVLFLDGID
|
|
|
|---|
| BDBM50286545 |
|---|
| n/a |
|---|
| Name | BDBM50286545 |
|---|
| Synonyms: | 3-Benzenesulfonyl-5-chloro-2-(1H-imidazol-2-yl)-1H-indole | CHEMBL148371 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H12ClN3O2S |
|---|
| Mol. Mass. | 357.814 |
|---|
| SMILES | Clc1ccc2[nH]c(-c3ncc[nH]3)c(c2c1)S(=O)(=O)c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
