| Reaction Details |
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 | Report a problem with these data |
| Target | Interstitial collagenase |
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| Ligand | BDBM50287603 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_101740 |
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| IC50 | 7000±n/a nM |
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| Citation |  Foley, MA; Hassman, AS; Drewry, DH; Greer, DG; Wagner, CD; Feldman, PL; Berman, J; Bickett, DM; McGeehan, GM; Lambert, MH; Green, M Rapid synthesis of novel dipeptide inhibitors of human collagenase and gelatinase using solid phase chemistry Bioorg Med Chem Lett6:1905-1910 (1996) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Interstitial collagenase |
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| Name: | Interstitial collagenase |
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| Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 54010.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P03956 |
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| Residue: | 469 |
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| Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
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| BDBM50287603 |
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| n/a |
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| Name | BDBM50287603 |
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| Synonyms: | (S)-2-((R)-2-Acetylamino-3-mercapto-propionylamino)-3-methyl-butyramide | CHEMBL56192 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H19N3O3S |
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| Mol. Mass. | 261.341 |
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| SMILES | CC(C)[C@H](NC(=O)[C@H](CS)NC(C)=O)C(N)=O |
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| Structure | 
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