Reaction Details | |||
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Target | Neprilysin | ||
Ligand | BDBM50287699 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEBML_144623 | ||
Ki | 0.600000±n/a nM | ||
Citation | Beight, DW; Mehdi, S; Koehl, JR; Flynn, GA Synthesis of constrained thiorphan analogs as inhibitors of neutral endopeptidase Bioorg Med Chem Lett6:2053-2058 (1996) Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Neprilysin | |||
Name: | Neprilysin | ||
Synonyms: | Mme | NEP_RAT | Neprilysin | Neutral Endopeptidase (NEP) | Neutral endopeptidase 24.11 | ||
Type: | Protein | ||
Mol. Mass.: | 85789.59 | ||
Organism: | Rattus norvegicus (Rat) | ||
Description: | P07861 | ||
Residue: | 750 | ||
Sequence: |
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BDBM50287699 | |||
n/a | |||
Name | BDBM50287699 | ||
Synonyms: | 4-[(2-Mercaptomethyl-1,2,3,4-tetrahydro-naphthalene-2-carbonyl)-amino]-cyclohexanecarboxylic acid | CHEMBL62535 | ||
Type | Small organic molecule | ||
Emp. Form. | C19H25NO3S | ||
Mol. Mass. | 347.472 | ||
SMILES | OC(=O)C1CCC(CC1)NC(=O)C1(CS)CCc2ccccc2C1 |(19.02,-7.43,;17.57,-6.91,;17.3,-5.39,;16.39,-7.89,;16.39,-9.43,;15.5,-8.45,;13.75,-8.17,;13.77,-6.63,;14.58,-7.58,;12.44,-8.97,;11.09,-8.22,;11.08,-6.68,;9.76,-8.99,;9.76,-10.53,;11.08,-11.32,;9.76,-7.44,;8.43,-6.67,;7.1,-7.45,;5.76,-6.68,;4.43,-7.45,;4.43,-8.99,;5.76,-9.76,;7.09,-8.99,;8.43,-9.76,)| | ||
Structure |