| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Neprilysin |
|---|
| Ligand | BDBM50287700 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_144623 |
|---|
| Ki | 0.500000±n/a nM |
|---|
| Citation |  Beight, DW; Mehdi, S; Koehl, JR; Flynn, GA Synthesis of constrained thiorphan analogs as inhibitors of neutral endopeptidase Bioorg Med Chem Lett6:2053-2058 (1996) Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Neprilysin |
|---|
| Name: | Neprilysin |
|---|
| Synonyms: | Mme | NEP_RAT | Neprilysin | Neutral Endopeptidase (NEP) | Neutral endopeptidase 24.11 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 85789.59 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | P07861 |
|---|
| Residue: | 750 |
|---|
| Sequence: | MGRSESQMDITDINAPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSS
DCIKSAARLIQNMDASAEPCTDFFKYACGGWLKRNVIPETSSRYSNFDILRDELEVILKD
VLQEPKTEDIVAVQKAKTLYRSCINESAIDSRGGQPLLTLLPDIYGWPVASQNWEQTYGT
SWTAEKSIAQLNSKYGKKVLINFFVGTDDKNSTQHIIHFDQPRLGLPSRDYYECTGIYKE
ACTAYVDFMISVARLIRQEQRLPIDENQLSLEMNKVMELEKEIANATTKPEDRNDPMLLY
NKMTLAKLQNNFSLEINGKPFSWSNFTNEIMSTVNINIQNEEEVVVYAPEYLTKLKPILT
KYSPRDLQNLMSWRFIMDLVSSLSRNYKESRNAFRKALYGTTSETATWRRCANYVNGNME
NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKKAEEKALAIKERI
GYPDDIISNENKLNNEYLELNYKEEEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAA
VVNAFYSSGRNQIVFPAGILQPPFFSARQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD
GDLVDWWTQQSANNFKDQSQCMVYQYGNFTWDLAGGQHLNGINTLGENIADNGGIGQAYR
AYQNYVKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII
GTLQNSAEFADAFHCRKNSYMNPERKCRVW
|
|
|
|---|
| BDBM50287700 |
|---|
| n/a |
|---|
| Name | BDBM50287700 |
|---|
| Synonyms: | (S)-3-(4-Hydroxy-phenyl)-2-[(2-mercaptomethyl-1,2,3,4-tetrahydro-naphthalene-2-carbonyl)-amino]-propionic acid benzyl ester | CHEMBL294760 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H29NO4S |
|---|
| Mol. Mass. | 475.599 |
|---|
| SMILES | Oc1ccc(C[C@H](NC(=O)C2(CS)CCc3ccccc3C2)C(=O)OCc2ccccc2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
