| Reaction Details |
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 | Report a problem with these data |
| Target | Squalene synthase |
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| Ligand | BDBM50288129 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_202101 |
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| IC50 | 9±n/a nM |
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| Citation |  Brinkman, JA; Damon, RE; Fell, JB; Perez, LB; Scallen, TJ; Vedamanda, TR Squalene synthase inhibitors: isosteric replacements of the farnesyl chain of benzyl farnesyl amine Bioorg Med Chem Lett6:2491-2494 (1996) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Squalene synthase |
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| Name: | Squalene synthase |
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| Synonyms: | FDFT_RAT | FPP:FPP farnesyltransferase | Farnesyl-diphosphate farnesyltransferase | Fdft1 | SQS | SS | Squalene synthetase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48109.41 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1336736 |
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| Residue: | 416 |
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| Sequence: | MEFVKCLGHPEEFYNLLRFRMGGRRNFIPKMDRNSLSNSLKTCYKYLDQTSRSFAAVIQA
LDGDIRHAVCVFYLILRAMDTVEDDMAISVEKKIPLLRNFHTFLYEPEWRFTESKEKHRV
VLEDFPTISLEFRNLAEKYQTVIADICHRMGCGMAEFLNKDVTSKQDWDKYCHYVAGLVG
IGLSRLFSASEFEDPIVGEDTECANSMGLFLQKTNIIRDYLEDQQEGRQFWPQEVWGKYV
KKLEDFVKPENVDVAVKCLNELITNALQHIPDVITYLSRLRNQSVFNFCAIPQVMAIATL
AACYNNHQVFKGVVKIRKGQAVTLMMDATNMPAVKAIIYQYIEEIYHRVPNSDPSASKAK
QLISNIRTQSLPNCQLISRSHYSPIYLSFIMLLAALSWQYLSTLSQVTEDYVQREH
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| BDBM50288129 |
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| n/a |
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| Name | BDBM50288129 |
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| Synonyms: | (2-Phenyl-propyl)-{2-[4-((E)-styryl)-phenoxy]-ethyl}-amine | CHEMBL83546 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H27NO |
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| Mol. Mass. | 357.488 |
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| SMILES | CC(CNCCOc1ccc(\C=C\c2ccccc2)cc1)c1ccccc1 |
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| Structure | 
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