Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
GTPase KRas (Homo sapiens (Human)) | BDBM50539763 (Adagrasib | Mrtx-849 | Mrtx849) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | 3.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc Curated by ChEMBL | Assay Description Inhibition of recombinant KRAS G12C mutant (unknown origin) assessed as rate of inactivation by LC-MS analysis | J Med Chem 63: 6679-6693 (2020) Article DOI: 10.1021/acs.jmedchem.9b02052 BindingDB Entry DOI: 10.7270/Q2G164C5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas (Homo sapiens (Human)) | BDBM50503649 (CHEMBL4476113) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | PDB Article PubMed | 2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of KRAS G12C mutant (unknown origin) | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01688 BindingDB Entry DOI: 10.7270/Q2TM7G15 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
GTPase KRas [G12D] (Homo sapiens (Human)) | BDBM617349 (US20230279025, Example 465) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | 0.00100 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q2QR5281 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas [G12D] (Homo sapiens (Human)) | BDBM617357 (US20230279025, Example 469) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | <0.00200 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q2QR5281 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas [G12D] (Homo sapiens (Human)) | BDBM617363 (US20230279025, Example 482) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | <0.00200 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q2QR5281 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas [G12D] (Homo sapiens (Human)) | BDBM617323 (US20230279025, Example 452 | US20230279025, Exampl...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | <0.00200 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q2QR5281 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas [G12D] (Homo sapiens (Human)) | BDBM617355 (US20230279025, Example 468) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | <0.00200 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q2QR5281 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas [G12D] (Homo sapiens (Human)) | BDBM573400 (US11453683, Example 259 | US20230279025, Example 4...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | <0.00200 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q2QR5281 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas [G12D] (Homo sapiens (Human)) | BDBM50579601 (CHEMBL4858364 | US11453683, Example 252 | US202302...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | n/a | n/a | <0.00200 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q2QR5281 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas [G12D] (Homo sapiens (Human)) | BDBM617351 (US20230279025, Example 466) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | 0.00600 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q2QR5281 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas [G12D] (Homo sapiens (Human)) | BDBM617347 (US20230279025, Example 464) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | 0.00700 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q2QR5281 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas [G12D] (Homo sapiens (Human)) | BDBM617345 (US20230279025, Example 463) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | 0.0120 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q2QR5281 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas [G12D] (Homo sapiens (Human)) | BDBM617339 (US20230279025, Example 460) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | 0.0270 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q2QR5281 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas [G12D] (Homo sapiens (Human)) | BDBM616938 (US20230279025, Example 26 | US20230279025, Example...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | 0.0620 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q2QR5281 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas [G12D] (Homo sapiens (Human)) | BDBM573426 (US11453683, Example 284 | US20230279025, Example 2...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Table 2: The ability of a compound to bind to KRAS G12D was measured using a TR-FRET displacement assay. Biotinylated GDP-loaded recombinant human KR... | Citation and Details BindingDB Entry DOI: 10.7270/Q2PR807K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas [G12D] (Homo sapiens (Human)) | BDBM573426 (US11453683, Example 284 | US20230279025, Example 2...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q2QR5281 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas [G12D] (Homo sapiens (Human)) | BDBM50579600 (CHEMBL4857438 | US11453683, Example 251 | US202302...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Table 2: The ability of a compound to bind to KRAS G12D was measured using a TR-FRET displacement assay. Biotinylated GDP-loaded recombinant human KR... | Citation and Details BindingDB Entry DOI: 10.7270/Q2PR807K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas [G12D] (Homo sapiens (Human)) | BDBM50579600 (CHEMBL4857438 | US11453683, Example 251 | US202302...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q2QR5281 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas [G12D] (Homo sapiens (Human)) | BDBM50579595 (CHEMBL4863339 | US11453683, Example 185 | US202302...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Table 2: The ability of a compound to bind to KRAS G12D was measured using a TR-FRET displacement assay. Biotinylated GDP-loaded recombinant human KR... | Citation and Details BindingDB Entry DOI: 10.7270/Q2PR807K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas [G12D] (Homo sapiens (Human)) | BDBM50579595 (CHEMBL4863339 | US11453683, Example 185 | US202302...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q2QR5281 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas [G12D] (Homo sapiens (Human)) | BDBM573433 (US11453683, Example 63 | US20230279025, Example 63) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Table 2: The ability of a compound to bind to KRAS G12D was measured using a TR-FRET displacement assay. Biotinylated GDP-loaded recombinant human KR... | Citation and Details BindingDB Entry DOI: 10.7270/Q2PR807K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas [G12D] (Homo sapiens (Human)) | BDBM50579597 (CHEMBL4876040 | US11453683, Example 243 | US202302...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Table 2: The ability of a compound to bind to KRAS G12D was measured using a TR-FRET displacement assay. Biotinylated GDP-loaded recombinant human KR... | Citation and Details BindingDB Entry DOI: 10.7270/Q2PR807K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas [G12D] (Homo sapiens (Human)) | BDBM50579594 (CHEMBL4859236 | US11453683, Example 36 | US2023027...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Table 2: The ability of a compound to bind to KRAS G12D was measured using a TR-FRET displacement assay. Biotinylated GDP-loaded recombinant human KR... | Citation and Details BindingDB Entry DOI: 10.7270/Q2PR807K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas [G12D] (Homo sapiens (Human)) | BDBM573484 (US11453683, Example 340 | US20230279025, Example 3...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Table 2: The ability of a compound to bind to KRAS G12D was measured using a TR-FRET displacement assay. Biotinylated GDP-loaded recombinant human KR... | Citation and Details BindingDB Entry DOI: 10.7270/Q2PR807K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas [G12D] (Homo sapiens (Human)) | BDBM573644 (US11453683, Example 439 | US20230279025, Example 4...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Table 2: The ability of a compound to bind to KRAS G12D was measured using a TR-FRET displacement assay. Biotinylated GDP-loaded recombinant human KR... | Citation and Details BindingDB Entry DOI: 10.7270/Q2PR807K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas [G12D] (Homo sapiens (Human)) | BDBM573484 (US11453683, Example 340 | US20230279025, Example 3...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q2QR5281 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas [G12D] (Homo sapiens (Human)) | BDBM573644 (US11453683, Example 439 | US20230279025, Example 4...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q2QR5281 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas [G12D] (Homo sapiens (Human)) | BDBM573433 (US11453683, Example 63 | US20230279025, Example 63) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q2QR5281 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas [G12D] (Homo sapiens (Human)) | BDBM50579597 (CHEMBL4876040 | US11453683, Example 243 | US202302...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q2QR5281 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas [G12D] (Homo sapiens (Human)) | BDBM50579594 (CHEMBL4859236 | US11453683, Example 36 | US2023027...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q2QR5281 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas [G12D] (Homo sapiens (Human)) | BDBM50579601 (CHEMBL4858364 | US11453683, Example 252 | US202302...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Table 2: The ability of a compound to bind to KRAS G12D was measured using a TR-FRET displacement assay. Biotinylated GDP-loaded recombinant human KR... | Citation and Details BindingDB Entry DOI: 10.7270/Q2PR807K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas [G12D] (Homo sapiens (Human)) | BDBM50579601 (CHEMBL4858364 | US11453683, Example 252 | US202302...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q2QR5281 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas [G12D] (Homo sapiens (Human)) | BDBM573598 (US11453683, Example 189 | US20230279025, Example 1...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid PDB UniChem | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q2QR5281 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas [G12D] (Homo sapiens (Human)) | BDBM573424 (US11453683, Example 282 | US11453683, Example 366 ...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q2QR5281 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas [G12D] (Homo sapiens (Human)) | BDBM573647 (US11453683, Example 441 | US20230279025, Example 4...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q2QR5281 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas [G12D] (Homo sapiens (Human)) | BDBM573266 (US11453683, Example 109 | US20230279025, Example 1...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q2QR5281 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas [G12D] (Homo sapiens (Human)) | BDBM573647 (US11453683, Example 441 | US20230279025, Example 4...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Table 2: The ability of a compound to bind to KRAS G12D was measured using a TR-FRET displacement assay. Biotinylated GDP-loaded recombinant human KR... | Citation and Details BindingDB Entry DOI: 10.7270/Q2PR807K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas [G12D] (Homo sapiens (Human)) | BDBM573424 (US11453683, Example 282 | US11453683, Example 366 ...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Table 2: The ability of a compound to bind to KRAS G12D was measured using a TR-FRET displacement assay. Biotinylated GDP-loaded recombinant human KR... | Citation and Details BindingDB Entry DOI: 10.7270/Q2PR807K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas [G12D] (Homo sapiens (Human)) | BDBM573598 (US11453683, Example 189 | US20230279025, Example 1...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid PDB UniChem | US Patent | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Table 2: The ability of a compound to bind to KRAS G12D was measured using a TR-FRET displacement assay. Biotinylated GDP-loaded recombinant human KR... | Citation and Details BindingDB Entry DOI: 10.7270/Q2PR807K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas [G12D] (Homo sapiens (Human)) | BDBM573266 (US11453683, Example 109 | US20230279025, Example 1...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Table 2: The ability of a compound to bind to KRAS G12D was measured using a TR-FRET displacement assay. Biotinylated GDP-loaded recombinant human KR... | Citation and Details BindingDB Entry DOI: 10.7270/Q2PR807K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas [G12D] (Homo sapiens (Human)) | BDBM50579598 (CHEMBL4857719 | US11453683, Example 245 | US202302...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Table 2: The ability of a compound to bind to KRAS G12D was measured using a TR-FRET displacement assay. Biotinylated GDP-loaded recombinant human KR... | Citation and Details BindingDB Entry DOI: 10.7270/Q2PR807K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas [G12D] (Homo sapiens (Human)) | BDBM50579598 (CHEMBL4857719 | US11453683, Example 245 | US202302...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q2QR5281 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase mTOR (Homo sapiens (Human)) | BDBM136478 (US8865726, 109) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.510 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Array BioPharma Inc. US Patent | Assay Description The ability of compounds of Formula I to inhibit mTOR was determined in a radioactive filtration assay that measures the transfer of radiolabeled pho... | US Patent US8865726 (2014) BindingDB Entry DOI: 10.7270/Q2V69H93 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase mTOR (Homo sapiens (Human)) | BDBM136474 (US8865726, 105 | US8865726, 140) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.510 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Array BioPharma Inc. US Patent | Assay Description The ability of compounds of Formula I to inhibit mTOR was determined in a radioactive filtration assay that measures the transfer of radiolabeled pho... | US Patent US8865726 (2014) BindingDB Entry DOI: 10.7270/Q2V69H93 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase mTOR (Homo sapiens (Human)) | BDBM136465 (US8865726, 96) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.510 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Array BioPharma Inc. US Patent | Assay Description The ability of compounds of Formula I to inhibit mTOR was determined in a radioactive filtration assay that measures the transfer of radiolabeled pho... | US Patent US8865726 (2014) BindingDB Entry DOI: 10.7270/Q2V69H93 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas [G12D] (Homo sapiens (Human)) | BDBM50579596 (CHEMBL4867851 | US11453683, Example 232 | US202302...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Table 2: The ability of a compound to bind to KRAS G12D was measured using a TR-FRET displacement assay. Biotinylated GDP-loaded recombinant human KR... | Citation and Details BindingDB Entry DOI: 10.7270/Q2PR807K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas [G12D] (Homo sapiens (Human)) | BDBM50579604 (CHEMBL4876243 | US11453683, Example 388 | US202302...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Table 2: The ability of a compound to bind to KRAS G12D was measured using a TR-FRET displacement assay. Biotinylated GDP-loaded recombinant human KR... | Citation and Details BindingDB Entry DOI: 10.7270/Q2PR807K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas [G12D] (Homo sapiens (Human)) | BDBM50579596 (CHEMBL4867851 | US11453683, Example 232 | US202302...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q2QR5281 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas [G12D] (Homo sapiens (Human)) | BDBM573462 (US11453683, Example 314 | US20230279025, Example 3...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Table 2: The ability of a compound to bind to KRAS G12D was measured using a TR-FRET displacement assay. Biotinylated GDP-loaded recombinant human KR... | Citation and Details BindingDB Entry DOI: 10.7270/Q2PR807K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas [G12D] (Homo sapiens (Human)) | BDBM50579604 (CHEMBL4876243 | US11453683, Example 388 | US202302...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q2QR5281 | ||||||||||||
More data for this Ligand-Target Pair |
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