| Reaction Details |
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 | Report a problem with these data |
| Target | GTPase KRas [G12D] |
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| Ligand | BDBM617339 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition of KRas G12D-mediated Phosphorylation of ERK |
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| IC50 | 0.027±n/a nM |
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| Citation |  Wang, X; Burns, AC; Christensen, JG; Ketcham, JM; Lawson, JD; Marx, MA; Smith, CR; Allen, S; Blake, JF; Chicarelli, MJ; Dahlke, JR; Dai, D; Fell, JB; Fischer, JP; Mejia, MJ; Newhouse, B; Nguyen, P; O''Leary, JM; Pajk, S; Rodriguez, ME; Savechenkov, P; Tang, TP; Vigers, GP; Zhao, Q; Kahn, DR; Gaudino, J; Hilton, MC KRAS G12D INHIBITORS US Patent US20230279025 Publication Date 9/7/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| GTPase KRas [G12D] |
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| Name: | GTPase KRas [G12D] |
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| Synonyms: | GTPase KRas (G12D) | KRAS | KRAS2 | RASK2 | RASK_HUMAN |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 21713.12 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P01116[G12D] |
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| Residue: | 189 |
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| Sequence: | MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC
VKIKKCIIM
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| BDBM617339 |
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| n/a |
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| Name | BDBM617339 |
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| Synonyms: | US20230279025, Example 460 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H32F2N6O |
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| Mol. Mass. | 542.6222 |
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| SMILES | Fc1ccc2cccc(-c3ncc4c(nc(OCC56CCCN5CCC6)nc4c3F)N3CC4CCC(C3)N4)c2c1 |
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| Structure | 
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