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TargetProstaglandin G/H synthase 1
LigandBDBM50288391
Substrate/Competitorn/a
Meas. Tech.ChEBML_159273
IC50>1000000±n/a nM
Citation Pinto, DJCopeland, RACovington, MBPitts, WJBatt, DGOrwat, MJLam, GNJoshi, AChan, YCWang, STrzaskos, JMMagolda, RLKornhauser, DM Chemistry and pharmacokinetics of diarylthiophenes and terphenyls as selective COX-2 inhibitors Bioorg Med Chem Lett6:2907-2912 (1996)    Article
More Info.:Get all data from this article,  Assay Method
 
Prostaglandin G/H synthase 1
Name:Prostaglandin G/H synthase 1
Synonyms:COX1 | Cyclooxygenase-1 | Cyclooxygenase-1 (COX-1) | PGH1_SHEEP | PTGS1 | Prostaglandin G/H synthase (cyclooxygenase)
Type:Protein
Mol. Mass.:68868.60
Organism:Ovis aries (Sheep)
Description:n/a
Residue:600
Sequence:
MSRQSISLRFPLLLLLLSPSPVFSADPGAPAPVNPCCYYPCQHQGICVRFGLDRYQCDCT
RTGYSGPNCTIPEIWTWLRTTLRPSPSFIHFLLTHGRWLWDFVNATFIRDTLMRLVLTVR
SNLIPSPPTYNIAHDYISWESFSNVSYYTRILPSVPRDCPTPMDTKGKKQLPDAEFLSRR
FLLRRKFIPDPQSTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLER
QYQLRLFKDGKLKYQMLNGEVYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLML
YATIWLREHNRVCDLLKAEHPTWGDEQLFQTARLILIGETIKIVIEEYVQQLSGYFLQLK
FDPELLFGAQFQYRNRIAMEFNQLYHWHPLMPDSFRVGPQDYSYEQFLFNTSMLVDYGVE
ALVDAFSRQPAGRIGGGRNIDHHILHVAVDVIKESRVLRLQPFNEYRKRFGMKPYTSFQE
LTGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEMGAPFSLKGLLGNPIC
SPEYWKASTFGGEVGFNLVKTATLKKLVCLNTKTCPYVSFHVPDPRQEDRPGVERPPTEL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50288391
n/a
NameBDBM50288391
Synonyms:3-(4-Methanesulfonyl-phenyl)-2-p-tolyl-thiophene | CHEMBL99517
TypeSmall organic molecule
Emp. Form.C18H16O2S2
Mol. Mass.328.448
SMILESCc1ccc(cc1)-c1sccc1-c1ccc(cc1)S(C)(=O)=O
Structure
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