| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin-1 receptor |
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| Ligand | BDBM50289112 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_65330 |
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| IC50 | >440±n/a nM |
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| Citation |  Shibata, K; Yano, K; Tanaka, T; Matsuda, Y; Yamasaki, M Analogs of an endothelin antagonist RES-701-1: substitutions of C-terminal amino acid Bioorg Med Chem Lett6:775-778 (1996) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin-1 receptor |
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| Name: | Endothelin-1 receptor |
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| Synonyms: | EDNRA | EDNRA_BOVIN | ET-A | Endothelin A receptor | Endothelin receptor ET-A | Endothelin-1 receptor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48527.56 |
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| Organism: | Bos taurus |
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| Description: | ChEMBL_65329 |
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| Residue: | 427 |
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| Sequence: | METFWLRLSFWVALVGGVISDNPESYSTNLSIHVDSVATFHGTELSFVVTTHQPTNLALP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFEQNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYKGAQHRTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDTNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHEQNNHNTERS
SHKDSIN
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| BDBM50289112 |
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| n/a |
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| Name | BDBM50289112 |
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| Synonyms: | CHEMBL438745 | RES-701-1-C-terminal analogue |
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| Type | Small organic molecule |
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| Emp. Form. | C105H116N22O23 |
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| Mol. Mass. | 2054.1781 |
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| SMILES | C[C@@H](O)[C@H]1NC(=O)CNC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(N)=O)NC(=O)CNC(=O)C[C@@H](NC(=O)[C@H]2CCCN2C(=O)[C@H](C)NC1=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(O)=O |
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| Structure | 
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