Reaction Details |
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Target | 5-hydroxytryptamine receptor 2A |
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Ligand | BDBM50289605 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_2673 |
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Ki | 13±n/a nM |
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Citation | Mokrosz, MJ; Duszynska, B; Klodzinska, A; Deren-Wesolek, A; Chojnacka-Wójcik, E; Baranowski, TC; Abdou, IM; Redmore, NP; Strekowski, L 4-(3-furyl)-2-(4-methylpiperazino)pyrimidines: Potent 5-HT2A receptor antagonists Bioorg Med Chem Lett7:1635-1638 (1997) Article |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 2A |
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Name: | 5-hydroxytryptamine receptor 2A |
Synonyms: | 5-HT-2A | 5-HT2 | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_RAT | Htr2 | Htr2a | Serotonin Receptor 2A |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 52852.05 |
Organism: | Rattus norvegicus (rat) |
Description: | Rat cortex membranes 5-HT2A receptors. |
Residue: | 471 |
Sequence: | MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGY
LPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
MLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNP
IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF
VAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIH
REPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGA
LLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYK
SSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV
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BDBM50289605 |
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n/a |
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Name | BDBM50289605 |
Synonyms: | 4-Furan-2-yl-6-furan-3-yl-2-(4-methyl-piperazin-1-yl)-pyrimidine | CHEMBL42061 |
Type | Small organic molecule |
Emp. Form. | C17H18N4O2 |
Mol. Mass. | 310.3504 |
SMILES | CN1CCN(CC1)c1nc(cc(n1)-c1ccco1)-c1ccoc1 |
Structure |
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