| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Nitric oxide synthase, endothelial |
|---|
| Ligand | BDBM50072297 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_65319 |
|---|
| Ki | 810±n/a nM |
|---|
| Citation |  Shearer, BG; Lee, S; Franzmann, KW; White, HA; Sanders, DC; Kiff, RJ; Garvey, EP; Furfine, ES Conformationally restricted arginine analogues as inhibitors of human nitric oxide synthase Bioorg Med Chem Lett7:1763-1768 (1997) Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Nitric oxide synthase, endothelial |
|---|
| Name: | Nitric oxide synthase, endothelial |
|---|
| Synonyms: | Constitutive NOS | EC-NOS | Endothelial NOS | Endothelial nitric oxide synthase | NOS type III | NOS3 | NOS3_HUMAN | NOSIII | Nitric oxide synthase (inducible and endothelial) | Nitric oxide synthase, endothelial (eNOS) | Nitric-oxide synthase (endothelial and brain) | cNOS | eNOS |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 133297.84 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P29474 |
|---|
| Residue: | 1203 |
|---|
| Sequence: | MGNLKSVAQEPGPPCGLGLGLGLGLCGKQGPATPAPEPSRAPASLLPPAPEHSPPSSPLT
QPPEGPKFPRVKNWEVGSITYDTLSAQAQQDGPCTPRRCLGSLVFPRKLQGRPSPGPPAP
EQLLSQARDFINQYYSSIKRSGSQAHEQRLQEVEAEVAATGTYQLRESELVFGAKQAWRN
APRCVGRIQWGKLQVFDARDCRSAQEMFTYICNHIKYATNRGNLRSAITVFPQRCPGRGD
FRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDDPP
ELFLLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMST
EIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINVAVLHSYQLAKVTIVDH
HAATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPW
KGSAAKGTGITRKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQSYAQQLGR
LFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSS
PRPEQHKSYKIRFNSISCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHF
CAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQAACETFCVGEDAKAAA
RDIFSPKRSWKRQRYRLSAQAEGLQLLPGLIHVHRRKMFQATIRSVENLQSSKSTRATIL
VRLDTGGQEGLQYQPGDHIGVCPPNRPGLVEALLSRVEDPPAPTEPVAVEQLEKGSPGGP
PPGWVRDPRLPPCTLRQALTFFLDITSPPSPQLLRLLSTLAEEPREQQELEALSQDPRRY
EEWKWFRCPTLLEVLEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPSTHPGEIHLTVAVL
AYRTQDGLGPLHYGVCSTWLSQLKPGDPVPCFIRGAPSFRLPPDPSLPCILVGPGTGIAP
FRGFWQERLHDIESKGLQPTPMTLVFGCRCSQLDHLYRDEVQNAQQRGVFGRVLTAFSRE
PDNPKTYVQDILRTELAAEVHRVLCLERGHMFVCGDVTMATNVLQTVQRILATEGDMELD
EAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERQLRGAVPWAFDPPGSDT
NSP
|
|
|
|---|
| BDBM50072297 |
|---|
| n/a |
|---|
| Name | BDBM50072297 |
|---|
| Synonyms: | (S)-5-Acetimidoylamino-2-amino-pent | (S)-5-Acetimidoylamino-2-amino-pentanoic acid | 5-Acetimidoylamino-2-(S)-amino-pentanoic acid | CHEMBL11471 | L-NIO, 12 | N5-(1-iminoethyl)-L-ornithine | N5-IMINOETHYL-L-ORNITHINE |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C7H15N3O2 |
|---|
| Mol. Mass. | 173.2129 |
|---|
| SMILES | CC(N)=NCCC[C@H](N)C(O)=O |r,w:3.3| |
|---|
| Structure | 
|
|---|
Search and Browse
