| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin-1 receptor |
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| Ligand | BDBM50289728 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_63359 |
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| IC50 | 2600±n/a nM |
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| Citation |  Mederski, WW; Osswald, M; Dorsch, D; Christadler, M; Schmitges, CJ; Wilm, C 1,4-Diaryl-2-oxo-1,2-dihydro-quinoline-3-carboxylic acids as endothelin receptor antagonists Bioorg Med Chem Lett7:1883-1886 (1997) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin-1 receptor |
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| Name: | Endothelin-1 receptor |
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| Synonyms: | EDNRA_RAT | ENDOTHELIN A | Ednra | Endothelin receptor | Endothelin-1 receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 48256.91 |
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| Organism: | RAT |
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| Description: | ENDOTHELIN A EDNRA RAT::P26684 |
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| Residue: | 426 |
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| Sequence: | MGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTEFNFLGTTLQPPNLALP
SNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEQHRTCM
LNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSS
HKDSMN
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| BDBM50289728 |
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| n/a |
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| Name | BDBM50289728 |
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| Synonyms: | 4-Benzo[1,3]dioxol-5-yl-1-benzo[1,3]dioxol-5-ylmethyl-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid | CHEMBL56286 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H17NO7 |
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| Mol. Mass. | 443.405 |
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| SMILES | OC(=O)c1c(-c2ccc3OCOc3c2)c2ccccc2n(Cc2ccc3OCOc3c2)c1=O |
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| Structure | 
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