| Reaction Details |
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 | Report a problem with these data |
| Target | Substance-P receptor |
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| Ligand | BDBM50214734 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_143040 (CHEMBL750289) |
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| Ki | 631±n/a nM |
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| Citation |  Armour, DR; Aston, NM; Morriss, KM; Congreve, MS; Hawcock, AB; Marquess, D; Mordaunt, JE; Richards, SA; Ward, P 1,4-Benzodiazepin-2-one derived neurokinin-1 receptor antagonists Bioorg Med Chem Lett7:2037-2042 (1997) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Substance-P receptor |
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| Name: | Substance-P receptor |
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| Synonyms: | NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 46254.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25103 |
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| Residue: | 407 |
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| Sequence: | MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTIST
VVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
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| BDBM50214734 |
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| n/a |
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| Name | BDBM50214734 |
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| Synonyms: | CHEMBL302163 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H19F6N3O2 |
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| Mol. Mass. | 507.4277 |
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| SMILES | FC(F)(F)c1cc(CNC(=O)N2CC(=O)Nc3ccccc3C2c2ccccc2)cc(c1)C(F)(F)F |
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| Structure | 
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