| Reaction Details |
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 | Report a problem with these data |
| Target | Substance-K receptor |
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| Ligand | BDBM50290302 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_142720 |
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| IC50 | 10±n/a nM |
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| Citation |  Burkholder, TP; Kudlacz, EM; Maynard, GD; Liu, XG; Le, TB; Webster, ME; Horgan, SW; Wenstrup, DL; Freund, DW; Boyer, F; Bratton, L; Gross, RS; Knippenberg, RW; Logan, DE; Jones, BK; Chen, TM; Geary, JL; Correll, MA; Poole, JC; Mandagere, AK Synthesis and structure-activity relationships for a series of substituted pyrrolidine NK1/NK2 receptor antagonists Bioorg Med Chem Lett7:2531-2536 (1997) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Substance-K receptor |
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| Name: | Substance-K receptor |
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| Synonyms: | NK2R_MOUSE | Neurokinin 2 receptor | Tac2r | Tacr2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 43128.63 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_142720 |
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| Residue: | 384 |
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| Sequence: | MGAHASVTDTNILSGLESNATGVTAFSMPGWQLALWATAYLALVLVAVTGNATVIWIILA
HERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVS
IYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATK
CVVAWPNDNGGKMLLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHGANLR
HLQAKKKFVKAMVLVVVTFAICWLPYHLYFILGTFQEDIYYRKFIQQVYLALFWLAMSST
MYNPIIYCCLNHRFRSGFRLAFRCCPWGTPTEEDRLELTHTPSISRRVNRCHTKETLFMT
GDMTHSEATNGQVGGPQDGEPAGP
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| BDBM50290302 |
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| n/a |
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| Name | BDBM50290302 |
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| Synonyms: | 1-{2-[(R)-3-(3,4-Dichloro-phenyl)-1-(3,4,5-trimethoxy-benzoyl)-pyrrolidin-3-yl]-ethyl}-2,3,5,6-tetrahydro-1H-[4,4']bipyridinyl-4-carboxylic acid amide; hydrochloride | CHEMBL553554 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H38Cl2N4O5 |
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| Mol. Mass. | 641.585 |
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| SMILES | COc1cc(cc(OC)c1OC)C(=O)N1CC[C@@](CCN2CCC(CC2)(C(N)=O)c2ccncc2)(C1)c1ccc(Cl)c(Cl)c1 |r| |
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| Structure | 
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