Reaction Details |
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Target | Substance-P receptor |
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Ligand | BDBM50290462 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_142698 (CHEMBL744930) |
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Ki | 1.5±n/a nM |
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Citation | Fauchère, JL; Kucharczyk, N; Jacoby, E; Lonchampt, M; Robineau, P; Dacquet, C; Regoli, D; Canet, E The dipeptide neurokinin-1 receptor antagonist S19752 is a potent and long-acting inhibitor of bronchoconstriction when administered by aerosol to the guinea pig in vivo Bioorg Med Chem Lett7:203-208 (1997) Article |
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More Info.: | Get all data from this article, Assay Method |
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Substance-P receptor |
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Name: | Substance-P receptor |
Synonyms: | NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46254.43 |
Organism: | Homo sapiens (Human) |
Description: | P25103 |
Residue: | 407 |
Sequence: | MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTIST
VVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
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BDBM50290462 |
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n/a |
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Name | BDBM50290462 |
Synonyms: | CHEMBL305119 | potassium 2N-[1-benzyl(methyl)carbamoyl-2-(2-naphthyl)-(1S)-ethyl]-4-hydroxy-1-{1-[4-(1H-1,2,3,4-tetraazol-5-yl)butyl]-1H-3-indolylcarbonyl}-(2R,4S)-tetrahydro-1H-2-pyrrolecarboxamide |
Type | Small organic molecule |
Emp. Form. | C40H41N8O4 |
Mol. Mass. | 697.8053 |
SMILES | CN(Cc1ccccc1)C(=O)C(Cc1ccc2ccccc2c1)NC(=O)C1CC(O)CN1C(=O)c1cn(CCCCc2nn[n-]n2)c2ccccc12 |
Structure |
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