Reaction Details |
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Target | Substance-P receptor |
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Ligand | BDBM50290722 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_205406 |
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IC50 | 5.9±n/a nM |
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Citation | Vaz, RJ; Maynard, GD; Kudlacz, EM; Bratton, LD; Kane, JM; Shatzer, SA; Knippenberg, RW Use of CoMFA in validating the conformation used in designing 4-(1H-benzimidazole-2-carbonyl)piperidines with H1/NK1 receptor antagonist activity Bioorg Med Chem Lett7:2825-2830 (1997) Article |
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More Info.: | Get all data from this article, Assay Method |
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Substance-P receptor |
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Name: | Substance-P receptor |
Synonyms: | NK1R_CAVPO | Neurokinin 1 receptor | Neurokinin NK1 | TAC1R | TACR1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 46261.42 |
Organism: | GUINEA PIG |
Description: | Neurokinin NK1 TACR1 GUINEA PIG::P30547 |
Residue: | 407 |
Sequence: | MDNVLPVDSDLFPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPGRVVC
MIEWPSHPDKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAADYEGLEMKSTRYFQTQGSVYKVSRLETTIST
VVGAHEEDPEEGPKATPSSLDLTSNGSSRSNSKTVTESSSFYSNMLS
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BDBM50290722 |
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n/a |
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Name | BDBM50290722 |
Synonyms: | CHEMBL98076 | [1-(4-Fluoro-benzyl)-1H-benzoimidazol-2-yl]-{1-[2-(4-methoxy-phenyl)-ethyl]-piperidin-4-ylidene}-amine |
Type | Small organic molecule |
Emp. Form. | C28H29FN4O |
Mol. Mass. | 456.5545 |
SMILES | [#6]-[#8]-c1ccc(-[#6]-[#6]-[#7]-2-[#6]-[#6]\[#6](-[#6]-[#6]-2)=[#7]/c2nc3ccccc3n2-[#6]-c2ccc(F)cc2)cc1 |
Structure |
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