| Reaction Details |
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 | Report a problem with these data |
| Target | Cytosolic phospholipase A2 |
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| Ligand | BDBM50288286 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_81567 |
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| IC50 | 40000±n/a nM |
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| Citation |  Springer, DM; Luh, BY; D'Andrea, SV; Bronson, JJ; Mansuri, MM; Burke, JR; Gregor, KR; Stanley, PL; Tramposch, KM Dicarboxylic acid inhibitors of phospholipase A2 Bioorg Med Chem Lett7:793-798 (1997) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytosolic phospholipase A2 |
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| Name: | Cytosolic phospholipase A2 |
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| Synonyms: | CPLA2 | Lysophospholipase | PA24A_HUMAN | PLA2G4 | PLA2G4A | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2 | Phospholipase A2 group IVA |
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| Type: | Protein |
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| Mol. Mass.: | 85219.30 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P47712 |
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| Residue: | 749 |
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| Sequence: | MSFIDPYQHIIVEHQYSHKFTVVVLRATKVTKGAFGDMLDTPDPYVELFISTTPDSRKRT
RHFNNDINPVWNETFEFILDPNQENVLEITLMDANYVMDETLGTATFTVSSMKVGEKKEV
PFIFNQVTEMVLEMSLEVCSCPDLRFSMALCDQEKTFRQQRKEHIRESMKKLLGPKNSEG
LHSARDVPVVAILGSGGGFRAMVGFSGVMKALYESGILDCATYVAGLSGSTWYMSTLYSH
PDFPEKGPEEINEELMKNVSHNPLLLLTPQKVKRYVESLWKKKSSGQPVTFTDIFGMLIG
ETLIHNRMNTTLSSLKEKVNTAQCPLPLFTCLHVKPDVSELMFADWVEFSPYEIGMAKYG
TFMAPDLFGSKFFMGTVVKKYEENPLHFLMGVWGSAFSILFNRVLGVSGSQSRGSTMEEE
LENITTKHIVSNDSSDSDDESHEPKGTENEDAGSDYQSDNQASWIHRMIMALVSDSALFN
TREGRAGKVHNFMLGLNLNTSYPLSPLSDFATQDSFDDDELDAAVADPDEFERIYEPLDV
KSKKIHVVDSGLTFNLPYPLILRPQRGVDLIISFDFSARPSDSSPPFKELLLAEKWAKMN
KLPFPKIDPYVFDREGLKECYVFKPKNPDMEKDCPTIIHFVLANINFRKYRAPGVPRETE
EEKEIADFDIFDDPESPFSTFNFQYPNQAFKRLHDLMHFNTLNNIDVIKEAMVESIEYRR
QNPSRCSVSLSNVEARRFFNKEFLSKPKA
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| BDBM50288286 |
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| n/a |
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| Name | BDBM50288286 |
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| Synonyms: | 3-[(1E,3E,5E)-1-((E)-2-Carboxy-1-methyl-vinyl)-4-methyl-6-(2,6,6-trimethyl-cyclohex-1-enyl)-hexa-1,3,5-trienyl]-benzoic acid | BMS-181162 | CHEMBL313583 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H32O4 |
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| Mol. Mass. | 420.5406 |
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| SMILES | C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C(/C(/C)=C/C(O)=O)\c1cccc(c1)C(O)=O |c:4| |
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| Structure | 
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