| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin receptor type B |
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| Ligand | BDBM50292477 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_507945 (CHEMBL937908) |
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| IC50 | >500000±n/a nM |
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| Citation |  Hussain, RA; Dickey, JK; Rosser, MP; Matson, JA; Kozlowski, MR; Brittain, RJ; Webb, ML; Rose, PM; Fernandes, P A Novel Class of Non-Peptidic Endothelin Antagonists Isolated from the Medicinal Herb Phyllanthus niruri J Nat Prod58:1515-1520 (1995) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin receptor type B |
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| Name: | Endothelin receptor type B |
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| Synonyms: | EDNRB | EDNRB_HUMAN | ENDOTHELIN B | ET-B | ETRB | Endothelin receptor ET-B | Endothelin receptor non-selective type | Endothelin receptor, ET-A/ET-B |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 49664.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ENDOTHELIN B EDNRB HUMAN::P24530 |
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| Residue: | 442 |
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| Sequence: | MQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNA
SLARSLAPAEVPKGDRTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNS
TLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFI
QKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGF
DIITMDYKGSYLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEM
LRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQNDPNRCEL
LSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSC
LKFKANDHGYDNFRSSNKYSSS
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| BDBM50292477 |
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| n/a |
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| Name | BDBM50292477 |
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| Synonyms: | CHEMBL453568 | phyllanthin |
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| Type | Small organic molecule |
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| Emp. Form. | C24H34O6 |
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| Mol. Mass. | 418.5232 |
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| SMILES | COC[C@H](Cc1ccc(OC)c(OC)c1)[C@H](COC)Cc1ccc(OC)c(OC)c1 |r| |
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| Structure | 
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