| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin-1 receptor |
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| Ligand | BDBM50292478 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_507944 (CHEMBL937907) |
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| IC50 | 160000±n/a nM |
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| Citation |  Hussain, RA; Dickey, JK; Rosser, MP; Matson, JA; Kozlowski, MR; Brittain, RJ; Webb, ML; Rose, PM; Fernandes, P A Novel Class of Non-Peptidic Endothelin Antagonists Isolated from the Medicinal Herb Phyllanthus niruri J Nat Prod58:1515-1520 (1995) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin-1 receptor |
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| Name: | Endothelin-1 receptor |
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| Synonyms: | EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 48736.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25101 |
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| Residue: | 427 |
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| Sequence: | METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRS
SHKDSMN
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| BDBM50292478 |
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| n/a |
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| Name | BDBM50292478 |
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| Synonyms: | (2S,4S)-5,8-dimethoxy-6-methyl-4-phenyl-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid | CHEMBL453823 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H22O4 |
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| Mol. Mass. | 326.3863 |
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| SMILES | COc1cc(C)c(OC)c2[C@@H](C[C@@H](Cc12)C(O)=O)c1ccccc1 |r| |
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| Structure | 
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