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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | DNA topoisomerase 1 | ||
| Ligand | BDBM50242279 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_482493 (CHEMBL956189) | ||
| IC50 | 40000±n/a nM | ||
| Citation |  Hecht, SM; Berry, DE; MacKenzie, LJ; Busby, RW; Nasuti, CA A Strategy for Identifying Novel, Mechanistically Unique Inhibitors of Topoisomerase I J Nat Prod55:401-413 (1992) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| DNA topoisomerase 1 | |||
| Name: | DNA topoisomerase 1 | ||
| Synonyms: | DNA topoisomerase I | DNA topoisomerase I (Topo I) | TOP1 | TOP1_HUMAN | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 90771.02 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P11387 | ||
| Residue: | 765 | ||
| Sequence: |
| ||
| BDBM50242279 | |||
| n/a | |||
| Name | BDBM50242279 | ||
| Synonyms: | 6,7,8,11,12,13,22,23-octahydroxy-3,16-dioxo-21-(3,4,5-trihydroxyphenylcarbonyloxy)-2,17,20-trioxatetracyclo[17.3.1.04,9.010,15]tricosa-4(9),5,7,10(15),11,13-hexaene | 6,7,8,11,12,13,22,23-octahydroxy-3,16-dioxo-21-(3,4,5-trihydroxyphenylcarbonyloxy)-2,17,20-trioxatetracyclo[17.3.1.04,9.010,15]tricosa-4,6,8,10,12,14-hexaene | CHEMBL449392 | Tannin analogue | corilagin | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H22O18 | ||
| Mol. Mass. | 634.4528 | ||
| SMILES | O[C@@H]1[C@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(O)c(O)c(O)cc3C(=O)O[C@@H]1[C@@H](O)[C@H](OC(=O)c1cc(O)c(O)c(O)c1)O2 |r| | ||
| Structure | 
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